| Objective:To observe the clinical effect of Jiawei Antai prescription in the treatment of recurrent abortion of kidney deficiency and blood stasis type,and to explore its mechanism,so as to provide an effective and safe medication scheme for clinical practice.Methods:from May 2019 to July 2020,76 patients with recurrent Spontaneous abortion in early pregnancy who met the inclusion criteria in the Affiliated Hospital of Jiangxi University of traditional Chinese medicine were collected,76 patients were randomly divided into treatment group and control group with 38 patients in each group.38 patients were treated with low molecular weight heparin and Jiawei Antai prescription(treatment group);38 patients were treated with low molecular weight heparin and traditional Chinese medicine placebo(control group).At the same time,the Traditional Chinese Medicine symptom score,RI、TT、 Pt、 D-dimer、 FIB、 Antithrombin Ⅲ、 pregnancy outcome and adverse reactions of the treatment group and the control group were compared before and after treatment,To evaluate the efficacy of the two treatment methods.monitor serum hormone(h CG、E2、P)levels once a week,and B-ultrasound monitoring were carried out Once a week to understand the embryonic development.liver function test was carried out Once a week,to detect the drug toxicity in time,so as to adjust the patient’s medication plan.Results:1.Comparison of TCM symptom scores: The TCM symptom score before and after treatment: treatment group(t=9.898,P<0.01);control group:(t=7.156,P<0.01),indicating that the treatment group and control group after treatment of TCM symptom score significantly decreased,the difference was statistically significant.Comparison treatment group and control group after treatment of TCM symptom score: t=2.328,P=0.023<0.05,treatment group TCM symptom score lower than control group,the difference was statistically significant.2.After 4 weeks of treatment(10 weeks of gestation),the average RI of uterine artery in the treatment group and the control group were significantly lower than that before treatment(6 weeks of gestation)(P< 0.01),and the average RI of uterine artery in the treatment group after treatment(10 weeks of gestation)was significantly lower than that in the control group(P < 0.01).3.comparison of six items of blood coagulation: the AT-III、PT、APTT、TT、D-Dimer、FIB:P value of the treatment group and the control group before treatment was greater than 0.05,indicating that there was no statistical difference between the two groups before treatment,and the difference between the t Thereatment group and the control group was statistically significant(P <0.01).4.The Comparison of total clinical efficacy: the total effective rate of the treatment group was 82.9% and the total effective rate of the control group was 58.3%.The total clinical efficacy of the treatment group was better than that of the control group(P<0.05).5.Comparison of abortion outcomes:Comparison of fetal abortion outcomes in treatment and control groups,in the treatment groups:30 were successful in treatment group,5 were failed,The success rate is 85.7%;In the control group,23 were successful,13 failed to Avoiding abortion.The success rate was 63.9%(2=4.467,P<0.05),It shows that the success rate of the treatment group is higher than that of the control group,The difference was statistically significant.6.Comparison of adverse reactions: during the treatment,The vital signs,Three routine checks,coagulation function,liver and kidney function,ECG of the two groups were examined,and all the indexes before and after treatment were within the normal reference value range.It shows that the treatment schemes of the two groups have certain safety,without obvious side effects.In the process of oral Chinese medicine decoction,there were 2 cases of nausea in the treatment group,After treatment,the patients were relieved and continued treatment.Conclusion:1.In treating RSA caused by PTS,The total effective rate of treatment group(Jiawei Antai prescription combined with low molecular weight heparin)was 82.9%,which was better than 58.3% in the control group(Chinese medicine placebo combined with low molecular weight heparin),It shows that tutor’s modified Jiawei Antai prescription based on Shoutai Pill and Huoxue Huayu herbs is safe and reliable in the clinical treatment of RSA of kidney deficiency and blood stasis type,and has very good clinical application effect,which is worthy of further promotion.2.The treatment group(Jiawei Antai prescription combined with LMWH)can obviously improve TCM syndrome score,six items of detection of coagulation function,uterine artery blood flow resistance index,and the curative effect is better than that of the control group.Quick effect,good curative effect and good safety are worth Ppularizing in clinic.3.The success rate of RSA caused by PTS in treatment group was85.7%,which was better than that of control group(placebo combined with LMWH)which was 63.9%. |
PDF Full Text Request