Clinical Study On Jiawei Shoutai Pills In The Treatment Of Recurrent Abortion Caused By Prethrombotic State Of Kidney Deficiency And Blood Stasis Syndrom

Objective: To take Jiawei Shou fetal pills combined with western medicine to treat patients with recurrent abortion(kidney deficiency and blood stasis syndrome)to relieve their clinical symptoms and improve pregnancy outcomes,and analyze the changes in the effect before and after treatment,so as to provide reference for clinicians to treat the disease.Methods:120 inpatients who were treated in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and met the criteria for pre-thrombotic recurrent abortion were collected.According to the physical and chemical examination results,they were divided into uterine arterial blood flow or D dimer abnormal group(Group A)and homocysteine abnormal group(Group B).Group A was randomly divided into two groups,including 30 cases with Jiawei Shou fetal pills and low-molecular heparin injection(Group A treatment group);30 cases with low-molecular heparin injection(Group A control group).Group B was randomly divided into two groups,including 30 cases using Jiawei Shou fetal pills and Ailewei(Group B treatment group);and 30 cases using Ailewei(Group B control group).Groups A and B were treated at the same time until 12 weeks of pregnancy.Observe the changes of TCM syndrome score,D-dimer,homocysteine and uterine artery blood flow resistance parameters of patients in groups A and B before and after treatment;compare the treatment effect of the treatment group and the successful pregnancy of the control group.Results:Ⅰ.Group A1.The age of the two groups and the number of previous spontaneous abortions,as well as the TCM syndrome score before treatment,D-dimer,uterine artery blood flow ultrasound examination,the difference is not statistically significant(P>0.05),and the two groups are comparable.2.D-dimer: The comparison between the two groups of patients before and after treatment had a significant difference(P<0.05);the comparison between the groups after treatment had a significant difference(P<0.05).3.Uterine artery blood flow resistance parameters:compared in the two groups before and after treatment,S/D,PI and RI have significant differences(P<0.05),which is of statistical significance;compared between the two groups of patients after treatment,S/D,PI and RI are significantly different(P<0.05),which is of statistically significant.4.TCM syndrome score: the comparison between the two groups of patients before and after treatment has a significant difference(P<0.05),which is of statistical significance;the comparison between the two groups of patients after treatment has a significant difference(P<0.05),which is of statistical significance.5.Pregnancy success rate: After the treatment,the pregnancy success rate of the two groups of patients was 93.33% and 73.33% respectively.The effect of the two groups was significant,and the difference was statistically significant(P<0.05),indicating that Jiaweishou fetal pills + low-molecular heparin injection can significantly improve the success rate of pregnancy.6.Safety analysis: The two groups of treatment plans were safe and did not produce obvious adverse reactions and side effects.Ⅱ.Group B1.The age and number of previous spontaneous abortions of the two groups,as well as the pre-treatment TCM syndrome score and homocysteine,the difference is not statistically significant(P>0.05),and the two groups are comparable.2.Homocysteine: There is a significant difference between the two groups of patients before and after treatment(P<0.05);after the comparison between the groups after treatment(P<0.05).3.TCM syndrome score: the comparison between the two groups of patients before and after treatment has a significant difference(P<0.05),which is of statistical significance;the comparison between the two groups of patients after treatment has a significant difference(P<0.05),which is of statistical significance.4.Pregnancy success rate: After the treatment,the pregnancy success rate of the two groups of patients was 90.00% and 66.67% respectively.The two groups had a significant curative effect,and the difference was statistically significant(P<0.05),indicating that Jiawei Shou fetal pills + Ailewei can significantly improve the pregnancy success rate.5.Safety analysis: The two groups of treatment plans were safe and did not produce obvious adverse reactions and side effects.Conclusion:Compared with the treatment of simple Western medicine,Jiaweishou fetal pills combined with Western medicine in the treatment of recurrent abortion(kidney deficiency and blood stasis syndrome)has obvious curative effects in terms of TCM syndrome points,uterine artery blood flow value(S/D,PI,RI),D-dimer,homocysteine and pregnancy success rate,and the safety is good.