Clinical Study Of Jiawei Jinkuishenqi Pills Combined With Bamboo Circle Ginger Moxibustion On Knee Palsy Of Liver And Kidney Deficiency

Purpose:Observe the clinical efficacy of Jiawei Jinkuishenqi Pills combined with bamboo circle ginger moxibustion in the treatment of liver and kidney deficiency type knee palsy by randomized controlled trials,and observe the changes in clinical symptoms,pain and functional scores of patients with liver and kidney deficiency type knee palsy before and after treatment,Provide a certain theoretical basis and practical demonstration for the internal and external treatment of traditional Chinese medicine in patients with knee palsy of liver and kidney deficiency.Method:The 120 patients with knee palsy with liver and kidney deficiency of one knee who met the inclusion criteria of this experiment were divided into groups A,B,C,and D using a random number table,with 30 patients in each group,a total of 4 groups,A total of 120 cases.All patients were instructed to reduce unreasonable activities,alcohol prohibition,low-fat diet and other basic treatments.Group A was treated with Jiawei Jinkuishenqi Pill,group B was treated with Zhuquan Ginger moxibustion,C was treated with Jiawei Jinkui Shenqi Pill combined with Zhuquan ginger moxibustion,and Group D was treated with diclofenac sodium sustained-release tablets.Each of the four groups received 2 courses of treatment,and 1 week was 1 course.Record and count the individual TCM symptom scores,TCM symptom scores,TCM symptom scores,NRS pain scores,WOMAC scores,inflammation indicators,and clinical efficacy data of the four groups of patients before and after treatment,and perform blood routine,liver and kidney functions,Safety testing such as electrocardiogram,recording adverse drug reactions.Statistical analysis of all data results using SPSS23.0 software,and finally to evaluate the effect of Jiawei Jinkuishenqi Pills combined with bamboo circle ginger moxibustion on liver and kidney deficiency type knee palsy,which is a clinical treatment for liver and kidney deficiency type knee palsy Explore more efficient treatment methods.Result:1.Comparison of baseline data: There was no statistically significant difference in the four groups in terms of age,gender,course of disease,and observation indexes before treatment(Chinese medicine symptom score,NRS score,inflammation index,WOMAC score),etc.(P>0.05).Comparability.2.Comparison in terms of improving the scores of individual symptoms of Chinese medicine: the scores of individual symptoms of traditional Chinese medicine after treatment in the four groups were all lower than before treatment,and the differences within each group were statistically significant(P<0.05).A pairwise comparison of the four groups after treatment showed that there was no significant difference in the improvement of TCM single symptom scores between group A,group B and group D(P>0.05);however,group C was significantly different from the three groups.(P<0.05);The data show that: in terms of improving the single symptoms of traditional Chinese medicine,the effects of group A,group B and group D are equivalent,but the effect of group C is significantly better than the other three groups.3.Comparison of total TCM symptom scores: The total TCM symptom scores of the four groups after treatment were all lower than those before treatment,and the differences within each group were statistically significant(P<0.05);the pairwise comparison of the four groups after treatment showed that A There was no statistically significant difference in the total scores of improving TCM symptoms between group,group B and group D(P>0.05);however,group C was significantly different from the other three groups(P<0.05);the data showed that: In terms of improving the total score of TCM symptoms,the effects of group A,group B and group D are equivalent,but the effect of group C is significantly better than the other three groups.4.Comparison of curative effect of TCM symptoms: After the four groups of treatment,the curative effect of TCM symptoms of group A,group B,group C and group D were 76.67%,73.33%,93.33% and 80.00%;after inspection,the curative effect of four groups of TCM symptoms The difference was statistically significant(P<0.05);after pairwise comparison,it was found that group A,group B,and group D had the same effect on the efficacy of TCM symptoms,but group C was significantly better than the other three groups in the efficacy of TCM symptoms.5.In terms of improving the NRS pain score: the NRS pain scores of the four groups after treatment were all lower than those before treatment,and the differences within each group were statistically significant(P<0.05).A pairwise comparison of the four groups after treatment showed that there was no statistically significant difference in the improvement of NRS pain scores between group A,group B and group D(P>0.05);however,group C was significantly different from the three groups(P>0.05).P<0.05);the data shows that: in terms of improving the NRS pain score,the effects of group A,group B and group D are equivalent,but the effect of group C is significantly better than the other three groups.6.In terms of improving WOMAC scores,the WOMAC scores of the four groups after treatment were all lower than before treatment,and the differences within each group were statistically significant(P<0.05).A pairwise comparison of the four groups after treatment showed that there was no statistically significant difference in the improvement of WOMAC scores between group A,group B,and group D(P>0.05);however,group C was significantly different from the three groups(P <0.05);The data show that: in terms of improving WOMAC score,the effects of group A,group B and group D are equivalent,but the effect of group C is significantly better than the other three groups.7.In terms of improving inflammation indexes,the inflammation indexes of the four groups after treatment were all lower than before treatment,and the differences within each group were statistically significant(P<0.05).A pairwise comparison of the four groups after treatment showed that there was no statistically significant difference in the improvement of inflammation indicators between group A,group B and group D(P>0.05);however,group C was significantly different from the three groups(P <0.05);The data show that: in terms of improving inflammation indexes,group A,group B and group D have the same effect in improving WOMAC score,but the decline of inflammation indexes in group C is significantly better than the other three groups.8.Comparison of clinical efficacy: After the treatment of the four groups,the total effective rates of group A,group B,group C and group D were 73.33%,70.00%,90.00% and 76.66%;after statistical testing,the total effective rate of the four groups The difference was statistically significant(P<0.05);after pairwise comparison,it was found that in terms of clinical efficacy,the clinical efficacy of group A,group B and group D were equivalent,but the effect of group C was significantly better than the other three groups.9.Adverse reactions and safety evaluation: No adverse reactions occurred in the four groups of patients during the treatment.The liver and kidney functions,the three major routines,and the electrocardiogram of the subjects before and after the treatment were normal,indicating that the four groups of drug treatments had no obvious side effects.Conclusion: The combination of Jiawei Jinkuishenqi Pills and bamboo circle ginger moxibustion significantly improves the clinical symptoms of patients with knee palsy with liver and kidney deficiency,and has achieved positive results.The short-term curative effect is good,and the long-term curative effect needs to be further studied.No obvious adverse reactions occurred in all patients during the study period,indicating that Jiawei Jinkuishenqi Pill combined with bamboo circle ginger moxibustion is an effective treatment for knee palsy due to liver and kidney deficiency.Combination therapy.