Study On The Treatment Of Migraine With Gastrodia-Uncaria Based On The Theory Of "Liver Wind"

Objective: To explore the effect of classical medicine of calming the liver and extinguishing the wind on the prevention and treatment of migraine by Gastrodia-Uncaria from the angle of "liver wind",and to provide theoretical basis for clinical treatment of migraine.Methods: To explore the pathogenesis of migraine and liver wind from the pathogenic factors,viscera relationship and meridian circulation.According to the potential pathogenesis of intrahepatic wind movement,the significance of classical medicine of calming the liver and extinguishing the wind on the treatment of liver wind was analyzed.Combined with the efficacy evaluation of Gastrodia-Uncaria on migraine model rats,the effect of Gastrodia-Uncaria on migraine model rats was confirmed and discussed The effect of pain is studied in this paper,focusing on the route of migraine liver wind and medicine of calming the liver and extinguishing the wind.Result:1.The head is the meeting of the sun,"on top of the mountain,only the wind can reach.".Liver is the dirty of wind wood,and it is connected with wind Qi outside.The wind belongs to Yang.It is active.Wind evil is the most likely to attack the head and cause headache."Wind is good and the number of changes" is similar to the pathogenic characteristics of headache with internal injury.2.Migraine wind refers to the internal wind with hyperactivity and inverse changes of Yang and Qi in the body,which is closely related to liver.The liver can turn wind into yin and Yang of Qi and blood.Among the pathogenic factors,there are potential pathogenesis of wind,such as heat pole,phlegm damp,blood stasis,yin deficiency and blood deficiency.External wind can lead to internal wind and internal wind can cause external wind.In the relationship between the viscera and the viscera,"liver is the thief of the five viscera","the five viscera and six viscera can generate wind,not only the liver but also the liver".Other viscera can also lead to the liver wind through the effect of the biological restraint.From the meridian,both liver and gallbladder channels follow the head,occupying the majority of the head."Foot Jueyin and Shaoyang Qi inversion" are headache.Migraine attack,often in the forehead,side pain,and liver,bile meridian follow the general same.3.Gastrodia-Uncaria,as a medicine for the combination of calming the liver and extinguishing the wind,can be traced back to the Yuan Dynasty,with a long history.In the pharmacodynamic evaluation experiment of Gastrodia Uncaria medicine on migraine model rats,the results showed that compared with the model group,the middle and high dose groups of Gastrodia-Uncaria medicine could significantly reduce the threshold of hot needling pain(P < 0.05),and alleviate migraine induced by nitroglycerin.Compared with the model group,the plasma concentrations of no and CGRP in the middle and high-dose groups were significantly lower(P < 0.05 or P < 0.01),the plasma concentrations of ET were significantly lower(P < 0.01),and the plasma concentrations of5-HT were significantly higher(P < 0.01).It is suggested that the combination of Gastrodia-Uncaria has better efficacy in the treatment of migraine and can alleviate the migraine induced by nitroglycerin.4.Although migraine has different syndrome types,it is always caused by the inverse changes of hyperemia of Qi and blood in the body.Liver wind,as a product of hyperactivity and inversion of Yang Qi,has been throughout the main line of migraine pathological evolution.Potential pathogenesis usually implies the trend of disease development and change.Therefore,for migraine,the drugs for relieving liver and wind are given to kill the pathogenesis change of Qi and blood disorder to the bud state.For the patients with liver wind disturbance,it is directly symptomatic treatment;for headache with syndrome of deficiency of blood,phlegm humidity,fire,liver depression,it is actually targeted for the potential pathogenesis.Conclusion:1."Liver is the thief of five organs","wind is the long of all diseases".From the angle of liver wind,the treatment of migraine with pinghepatican wind extinguishing medicine can often get good results.2.In the treatment of migraine,we should pay attention to the overall concept,grasp the potential pathogenesis,and use truncation therapy to treat Gastrodia-Uncaria,and to adjust liver yang to prevent the internal movement of liver wind.It plays an important role in the treatment of migraine attack,as well as in the prevention of migraine and disease prevention.