| Objectives:(1)To study the changes in plasm levels of Intermedin(IMD)in patients with heart failure(HF)and its correlation with brain natriuretic peptide(BNP);(2)To explore whether IMD affects heart function and its effects through oxidative stress mechanisms Correlation with reactive oxygen species(ROS)and superoxide dismutase(SOD).Methods:Selected 132 patients in the cardiology department of the Second Hospital of Shanda from January 2020 to October 2020,aged 45-80 years old,according to Framingham criteria,divided the patients into heart failure group(HF)78 cases(male 41 Patients and 37 females)and non-heart failure control group(CON)54 patients(23 males and 31 females).Collected the general information of all patients in the two groups and the relevant results of their biochemical :gender,age,BMI,liver and kidney function,etc.,and used enzyme-linked immunosorbent method(ELISA)to detect The serum levels of IMD,BNP,ROS and SOD in the two groups of patients.HF was divided into 3 groups according to LVEF: 20 cases of heart failure with HFr EF,22 cases of heart failure with HFmr EF,and heart failure with HFp EF Group 36 cases.According to NYHA cardiac function classification,HF was divided into 4 groups: 17 cases in grade I group,21 cases in grade Ⅱgroup,19 cases in grade Ⅲ group,and 21 cases example in grade Ⅳ group.Compare the general data,biochemical indicators,IMD,BNP,ROS and SOD levels of the HF group and the NHF control group,and analyze the differences in the levels of IMD in each group of heart failure classified by different methods.The correlation study of IMD and BNP,ROS and SOD in the heart failure group.This paper mainly uses SPSS25.0 software for statistical analysis of various data.Results:1.The general data and biochemical indicators of the heart failure group and the non-heart failure control group were compared.The details are as follows: systolic blood pressure(131.38±25.59,134.97±14.45),diastolic blood pressure(77.63±17.65,81.03±11.635),alanine in the HF group Transaminase [17.8(13.22,41.37),21.2(16.75,36.45)],low-density lipoprotein [1.94±0.79,2.28±0.65],apolipoprotein A-1(1.16±0.21,1.35±0.31),apolipoprotein The level of B-1(0.74±0.26,0.88±0.26)is lower than the CON group;age(67.46±12.16,60.74±9.31),body mass index [25.00(22.91,27.82),23.90(21.90,27.90)],Smoking [31(39.7%),18(33.3%)],glycosylated hemoglobin[6.2(5.7,7.4),6(5.45,7.73)],high-density lipoprotein [1.45±0.76,1.41±0.28],aspartame The levels of acid transaminase [22.6(17.4,35.25),21.5(18.05,25.95)],blood creatinine [74.5(58.09,101.25),65.395(54.25,74.645)] are higher than those in the CON group;except for age,LDL has statistics Except for the difference(P <0.05),there was no statistical difference(P>0.05).2.Compare the levels of IMD,SOD,ROS,and BNP in the HF group and the CON group(1)Compared with the CON group,the IMD level in the HF group increased [100.05(96.31,103.85)VS 99.47(92.96,101.01)P<0.05](2)Compared with the CON group,ROS in the HF group was increased(10.88±1.14 VS10.33±1.01 P<0.05).(3)Compared with the CON group,SOD activity was weakened in the HF group[40.25(35.76,45.68)VS 45.26(38.02,52.01)P<0.05].(4)Compared with the CON group,the BNP level in the HF group increased[725.15(173.32,1373.32)VS 30.52(19.48,63.73)P<0.05].3.Comparison of IMD levels between groups(1)In the HF group,comparing the IMD level between the HFr EF group(101.80±4.46),the HFmr EF group(101.34±6.33),and the HFp EF group(99.40±4.64),there were statistical differences,Compared with HFp EF group(99.40±4.64),IMD increased in the HFr EF group(101.80±4.46);compared with HFmr EF group(101.34±6.33),the IMD decreased in HFp EF group(99.40±4.64)and HFr EF group(101.80±4.46);P<0.05.(2)There were statistically significant differences in the levels of IMD among the four groups of cardiac function class I(97.64±4.54),class II group(100.41±4.42),class III group(101.36±5.82),and class IV group(102.36±50.5)(P<0.05).Compared with cardiac function group I(97.64±4.54),IMD in group III(101.36±5.82)and IV(102.36±50.5)increased;compared with cardiac function group II(100.41±4.42),IMD in group IV(102.36±50.5)increased;P<0.05.4.Binary Logistic regression analysis: After adjusting for other independent variables,it is concluded that age and IMD are independent risk factors that affect heart failure.5.Through ROC curve analysis: It is concluded that IMD and age have certain value in predicting the occurrence of heart failure.6.In the HF group,the correlation analysis between serum IMD and SOD,ROS,BNP(1)There was a negative correlation between serum SOD and IMD in the HF group,and the corresponding correlation coefficient was-0.984,P<0.05;(2)There was a positive correlation between serum IMD level and ROS level in the HF group,and the corresponding correlation coefficient was 0.882,P<0.05;(3)There was a positive correlation between IMD and BNP in the HF group,and the corresponding correlation coefficient was 0.231,P<0.05.7.MLR analysis shows that SOD and ROS are independent peril elements that affect IMD in patients with heart failure,and the activity of serum SOD in patients with heart failure has a more significant impact on IMD levels,which further indicates that IMD may inhibit body oxidation The stress level plays an anti-heart failure effect.Conclusions:1.The content of IMD in patients with heart failure increased significantly,and the increase was more significant in the heart failure group where the ejection fraction decreased,manifesting that IMD added with the exacerbation of HF.And in patients with HF,IMD level is positively correlated with BNP level,suggesting that IMD may have similar diagnostic value to BNP.Binary Logistic regression analysis shows that IMD is an independent factor affecting heart failure.ROC curve analysis IMD has a certain effect on heart failure The predictive value of IMD further elaborates that IMD may be used as an independent biological indicator for diagnosing heart failure and estimating prognosis.2.In patients with heart failure,SOD activity is weakened,ROS level is increased,and IMD is positively correlated with ROS and negatively correlated with SOD,indicating that the myocardium is damaged by oxidative stress during heart failure,and its antioxidant capacity is weakened,and oxidation should The increased response to excitement indicates that IMD may protect the myocardium by inhibiting the level of oxidative stress in the body.3.MLR analysis shows that SOD and ROD are independent peril elements that affect IMD in patients with HF,and the activity of SOD has a more significant impact on IMD levels,which further shows that IMD may exert anti-cardiac effects by inhibiting the body’s oxidative stress mechanism.Decay effect. |
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