Correlation Analysis Of Plasma Apolipoprotein B And The Degree Of Coronary Atherosclerosis

Objective:To explore the the correlation between plasma ApoB level and the degree of coronary atherosclerotic lesions in patients with chest pain.Methods:A retrospective analysis was conducted on 290 suspected CHD patients admitted to the Department of Cardiovascular Medicine of our hospital from 2017 to 2020 due to chest pain.According to the results of coronary angiography,they were divided into non-CHD group(n=81)and CHD group(n=209).The plasma ApoB level was measured by immunoturbidimetry,and the plasma ApoB level,other lipid indexes and clinical data between the two groups were compared.The CHD group was divided into low group(Gensini≤20 points,n=70),medium group(Gensini≤46 points,n=70),and high group(Gensini>46 points,n=69)according to the Gensini score.The plasma ApoB level,other lipid indexes and general data of the three groups were compared,and the indexes with statistically significant differences were analyzed and screened.Spearman correlation analysis was used to analyze the correlation between the indicators with statistical differences among the three groups and the severity of coronary artery disease.Multiple ordered Logistic regression was used to analyze the independent influencing factors of the severity of coronary artery disease.According to the number of coronary artery lesions,the patients were divided into 1 artery lesion group(n=35),2 artery lesion group(n=41),and 3 artery lesion group(n=133).The plasma ApoB levels of the three groups were compared to see if there was statistical difference.Results:1.Compared with the control group,the levels of age,smoking history,TC,TG,LDL-C and Lp(a),non-HDL,ApoB/ApoA in the CHD group were higher than those in the non-CHD group,with statistical significance(P < 0.05);The level of ApoA was lower than that of non-CHD group,and the difference was statistically significant(P < 0.05).2.Plasma ApoB level of CHD group 0.80g/L(0.64 g/L,1.05 g/L)was significantly higher than that of control group 0.67 g/L(0.56 g/L,0.75 g/L),the difference was statistically significant(P=0.000);3.The plasma ApoB level increased with the increase of coronary Ginsini score in the CHD group among the three groups,and the difference was statistically significant(P<0.05),which was consistent with the results of traditional lipid indexes TC,LDL-C and Lp(a),non-HDL,ApoB/ApoA;4.Spearman correlation analysis showed that ApoB was significantly correlated with the severity of coronary artery disease,which was consistent with the results of TC,LDL,ApoB/ApoA,non-HDL,Lp(a),and plasma ApoB had the strongest correlation with the severity of coronary artery disease(r=0.522).5.Multiple Logistic regression results showed that ApoB and Lp(a)were positively correlated with the severity of coronary artery disease(P<0.05,regression coefficient =2.955,P<0.05,regression coefficient =0.015),and ApoB and Lp(a)were independent influencing factors for the severity of coronary artery disease.6.There was no significant difference in plasma ApoB level among the three groups with different number of coronary artery disease(P > 0.05).Conclusion:Plasma ApoB increased with the increase of the severity of coronary atherosclerotic lesions,and was an independent risk factor for the severity of coronary artery lesions.