The Correlation Between Monocyte To High-density Lipoprotein Cholestrol Ratio And Carotid Artery Plaque And Its Stability In Middle-aged And Elderly Patients

Objective:The purpose of this study was to investigate the correlation between monocyte to high-density lipoprotein cholestrol ratio(MHR)and carotid artery plaque and its stability,and we’ll clarify the predictive value of MHR.Methods:A retrospective study was conducted.A total of 196 patients(age≥45 years old)from January 2016 to December 2019 who were admitted to the Geriatrics Department of the First Hospital of Shanxi Medical University were included.All the patients were divided into the plaque group(120 patients)and the non-plaque group(76 patients)according to the results of carotid artery ultrasound.The plaque group was further divided into two groups:the stable plaque group which included 56 patients and the unstable plaque group which included 64 patients.General informations of all patients were collected,and then all groups were compared separately.SPSS 21.0 software was used for statistical analysis.Normal distribution was represented by mean ±standard deviation((?)±s)while comparison between groups was represented by t test for measurement data,.Non-normal distribution was represented by M(Q1,Q3)while comparison between groups was performed by Mann-Whitn U rank sum test.Enumeration data was represented by percentage(%),and comparison between groups was performed by chi-square test.Multivariate logistic regression was used to analyze the risk factors of the plaque group and the unstable plaque group.In evaluating the predictive value of MHR for carotid artery unstable plaques,receiver operating characteristic(ROC)curve was used.The difference was statistically significant at P<0.1.Results:Comparison between plaque group and non-plaque group showed statistically significant differences in age,smoking,coronary heart disease,diabetes,cerebral infarction,hypertension,mean blood pressure level,lymphocyte count,monocyte count,MHR,Cys-C,phospholipids(P<0.1),while there were no statistically significant differences between two groups in other indicators(P>0.1).After compare general data between the stable plaque group and the unstable plaque group,statistically significant differences were observed in smoking,BMI,monocyte count,gender,high-density lipoprotein,MHR and Apo E(P<0.1),while the remaining indicators were not statistically significant(P>0.1).Multivariate logistic regression was used to analyze the risk factors of patients with carotid plaques.The results showed that MHR,smoking,age,and mean blood pressure were the risk factors for carotid plaques(respectively OR=13.910,95%CI 1.659-116.643,P=0.015;OR=2.664,95%CI 1.188-5.975,P=0.017;OR=1.100,95%CI 1.065-1.136,P=0.000;OR=1.034,95%CI 1.005-1.064,P=0.022).By the multivariate Logistic regression analysis of unstable plaque group,it can be observed that MHR and smoking were risk factors for unstable plaque(OR=2.792,95%CI 1.178-6.614,P=0.020;OR=63.044,95%CI4.908-809.755,P=0.001).The results of ROC curve showed that the AUC of MHR for predicting carotid unstable plaques was 0.724(95% CI was 0.630-0.817,P=0.000),the best cut off value was 0.415,the sensitivity was 84.4%,and the specificity was 57.1%,which suggested that MHR had a good predictive value in predicting carotid unstable plaques.Conclusion:As a risk factor for carotid plaque and unstable plaque,MHR has a good predictive value for carotid unstable plaque.It can be used to identify the stability of carotid plaque.