| Drug safety issues have become the focus of attention of all mankind.In the field of life sciences,domestic and foreign researchers focus on reducing diseases and increasing life expectancy,and devote themselves to research in the field of medicine.Among them,the separation of pharmaceutical ingredients and the removal of genotoxic impurities(GTIs)are closely related to human health,and the use of deep eutectic solvents(DESs)with good biocompatibility in the field of biomedicine is also increasingly extensive.In summary,DESs with structural designability,easy availability,and biocompatibility were prepared,and a series of DES-metal organic framework(MOF)luminescence systems were constructed for the separation of pharmaceutical ingredients and the construction of eutectic.The application of DES-functionalized biomass composite materials(Poly(DES)@Bio Ms)to the removal of GTIs are the main research content during my master’s period.The main research includes the following aspects:Chapter 1,IntroductionWe overview the research progress and development background of DESs and its related research,focusing on the overall development of research domestic and international research,as well as research in the field of medicine.This paper focuses on DESs as a new designable soft functional reagent in the direction of separation of pharmaceutical ingredients and removal of toxic impurities.Chapter 2,Visualized separation of pharmaceutical components by deep eutectic solventmetal organic framework system.We have prepared Ch Cl and Methyltriphenylphosphonium bromide series DESs,and combined with MOFs to prepare DES-MOF photoluminescence visualization separation system.And next,we have explored its application in the separation of pharmaceutical ingredients.The effects of 28 DESs on the luminescence properties of Zn-MOF-74 were analyzed experimentally,and the interaction and structure-activity changes between DESs and MOF were explored through scanning electron microscopy and Fourier infrared spectroscopy.We have explored the practical application of the DES-MOF system for the separation of pharmaceutical components,such as the exploration of the separation mechanism of polar components during the extraction of artemisinin.The results show that in the direction of visualization research,DESs have significant effect on the luminescence properties of MOFs.Experiments have proved that the DES-MOF system can separate the highly polar pharmaceutical components produced during the extraction of artemisinin,indicating that it has a prospect in the study of visual separation of pharmaceutical components.Chapter 3,Separation and removal of GTIs from biomass materials functionalized with eutectic solvents.According to the functional advantages of DESs and the natural characteristics of biomass(Bio M),18 green poly-deep eutectic solvents functionalized biomass materials(Poly(DES)@Bio Ms)were prepared to remove 5 GTIs.We have used scanning electron microscope,atomic force microscope and other instruments to characterize structural information;And we have used aromatic GTIs as the separation system to investigate the type,proportion,time,temperature,ionic strength,p H,etc.of DESs for specific removal of genotoxic impurities.In this work,the equilibrium/kinetic model and molecular simulation of the removal/release process of trace ppm of aromatic genotoxic impurities show that GTIs and Poly(DES)@Bio Ms are mainly through weak interactions such as hydrogen bonds.Force connection,Poly(DES)@Bio Ms’ deep removal mechanism for trace GTIs is based on multilayer,multiple and long-term interactions,among which the removal rate of three GTIs is more than 90%.In addition,Poly(DES)@Bio Ms can effectively remove trace GTIs in industrial sewage and pharmaceutical samples,confirming the removal performance of polymeric materials.Chapter 4,Conclusions and prospects... |
PDF Full Text Request