Effects Of Neonatal Asphyxia On Cardiac And Renal Function In Plateau Area

ObjectiveUnderstanding plateau neonatal asphyxia the impact of cardiovascular and renal function and serum troponin I(c Tn I),creatine kinase isoenzyme(CK-MB),cysteine proteinase inhibitor(Cystatin C),creatinine(Cr),urea nitrogen(BUN),routine urine,urine beta 2microglobulin(β2-MG),and other laboratory tests on neonatal asphyxia,middle of the back,the early diagnosis of kidney damage value and the value of condition monitoring,to improve and make a diagnosis and give treatment for clinical asphyxia children recognition ability.Methods1.Random not neonatal asphyxia in 50 cases(control group)and 22 cases of mild asphyxia neonates and 28 cases of severe asphyxia neonates(experimental group),collected the basic clinical data(such as gender,gestational age,birth weight,childbirth way,etc.),within one day after the birth to detect the serum c Tn I,CK-MB,Cystatin C,Cr,BUN,routine urine,urine β2-MG,Serum c Tn I,CK-MB,Cystatin C and urineβ2-MG were detected in children with mild and severe asthenia within 3days before discharge.2.The serum c Tn I,CK-MB,Cystatin C,Cr,BUN,urine routine and urineβ2-MG were compared between the three groups.3.The differences of serum c Tn I,CK-MB,Cystatin C and urine β2-MG in neonates with mild and severe asphyxia were compared in 1 day after birth and 3 days before discharge.Results1.The asphyxia group,the mild asphyxia group and severe asphyxia group(P = 0.969)between male and female ratio,birth gestational age(P= 0.565)and birth weight(P = 0.706)there was no difference(P > 0.05),on the childbirth way,asphyxia group(mild and severe)cesarean delivery rate was significantly higher than the asphyxia group(P < 0.05),mild asphyxia group and severe asphyxia between cesarean delivery rate was no significant difference(P > 0.05).2.On the first day after birth,c Tn I in severe asphyxia group was significantly higher than that in mild asphyxia group(P < 0.05),but there was no significant difference in CK-MB(P > 0.05);On the first day after birth,CK-MB in mild asphyxia group was significantly higher than that in non-asphyxia group,and there was no significant difference in c Tn I(P > 0.05).CK-MB and c Tn I in severe asphyxia group were higher than those in non-asphyxia group on the first day after birth(P < 0.001).3.There were no significant differences in Cr,BUN and urine routine among the three groups on the first day after birth(P > 0.05).β2-MG in mild asphyxia group was significantly higher than that in non-asphyxia group(P < 0.001),but there was no significant difference in Cystatin C(P > 0.05).The β2-Mg and Cystatin C levels in the severe asphyxia group were significantly higher than those in the mild asphyxia group and the non-asphyxia group on the first day after birth(P < 0.001).4.The levels of c Tn I,CK-MB,Cystatin C and β2-Mg in the asphyxia group(mild and severe)were significantly lower than those in the first day after birth(P <0.05).Conclusion1.Neonatal asphyxia in plateau area can have significant influence on cardiac and renal function.2.CTn I and CK-MB are of great value for the detection of early myocardial injury after neonatal asphyxia in the plateau area and the continuous monitoring of the condition.3.Cr、BUN and urine are not sensitive enough to identify early renal injury after neonatal asphyxia in the plateau area.Cystatin C and urineβ2-MG have important value for the detection of early renal injury after neonatal asphyxia and continuous monitoring of the condition.