Clinical Study Of Preoperative Peripheral Blood Inflammatory Markers In Predicting The Risk Of Postoperative Recurrence In Patients With Early-stage Lung Cancer

Primary bronchogenic carcinoma is the most common malignant tumor in the world.the earlier the stage of the tumor is found,the better the prognosis.Anatomical resection can obtain a good prognosis for patients with early non-small cell lung cancer,but some patients still have recurrence after surgical resection.Non-specific inflammatory biomarkers derived from peripheral blood cell count have been widely used as prognostic indicators of various malignant tumors in recent years.However,the best predictive index of inflammatory biomarkers for early NSCLC is not clear at present.The hospital computer system retrospectively analyzed the clinical data of patients with early NSCLC diagnosed after operation,and studied its predictive effect on the prognosis of early lung cancer by analyzing the non-specific inflammatory parameters related to preoperative whole blood cell count.A total of 227 patients with stage IA diagnosed pathologically after surgical resection from March 2016 to January 2020 were selected.Univariate and multivariate Cox ratio analysis of relapse-free survival rate(RFS)was used to detect systemic immune inflammation index(SII),neutrophil / lymphocyte ratio(NLR),platelet/ lymphocyte ratio(PLR)and monocyte / lymphocyte ratio(MLR)before operation.The clinical characteristics of the patients and the data analysis of preoperative peripheral blood inflammatory parameters showed that there is a significant correlation between high SII and postoperative recurrence(p=0.046).However,high MLR value was significantly correlated with sex(p=0.004),smoking status(p=0.001)and postoperative recurrence(p=0.002).NLR and PLR were not related to any related factors.Multivariate analysis showed that preoperative MLR level(paired 0.031)was an independent predictor of RFS found in this study.In the Kaplan-Meier analysis of preoperative PLR,SII,MLR and NLR values in patients with early NSCLC,it was found that the RFS values of high SII and MLR groups were significantly shorter than those of low SII and MLR groups.