Analysis Of Progranulin,clinical Risk Factors And MACE Events In ACS Patients And Plasma PLA2 Expression In STEMI Patients With Different Lipid Levels

Objective: To explore the composition structure of the ACS by collecting patient information.The common risk factors of ACS were statisanalyzed;the differences between ACS and stable angina in clinical risk factors and inpatient MACE were compared.Understand the correlation between risk factors and hospitalization complications.Forecast independent risk factors for ACS.Exploring correlation between lipid levels and Lp-PLA2 concentration;explore correlation of plasma particulate protein precursors(PGRN)levels and ACS to evaluate their diagnostic ability for ACS subgroups(UA,NSTEMI,STEMI).Methods:Collecting the patient data from First Lanzhou Hospital Heart Center in 2019.Statistical analysis analyzed common risk factors for ACS;Comparing differences between ACS and stable angina in clinical risk factors and inpatient MACE.Understand the correlation between risk factors and hospitalization complications.Concentrations of Lp-PLA2 in STEMI patients in hyperlipidemia and lipid normal were detected by the enzyme-linked immunosorption test(Elisa)and levels of granular protein precursors(PGRN)in plasma in normal populations of ACS and CAG.Results: With the progression of ACS pathology(control-UA-NSTEMI-STEMI),the PGRN level decreased gradually;Spearmans correlation analysis showed that PGRN level and age,white blood cell count,monocyte,neutrophils Negative correlation.With LVEF Positive correlation;Multivariate linear regression analysis suggested that PGRN level was an independent risk factor affecting ACS occurrence.Age,CK and CK-MB were independent risk factors for distinguishing STEMI from NSTEMI,UA and SAP.Patients’ age,Select the relevant case data of the Heart Center of the First Hospital of Lanzhou University in 2019 and conduct a systematic analysis to understand the corresponding incidence of ACS patients,and at the same time explore the composition of ACS,but significant correlation between MACE events,significant positive correlation between cardiac shock and death,and significant positive correlation between stent thrombosis and myocardial infarction recurrence.Finally,studies of STEMI patients with different LDL-C levels found that TC,HDL-C and PLA2 were independent risk factors for predicting LDL-C levels in STEMI patients.Conclusion: Plasma PGRN level is associated with ACS occurrence and is expected to be a new marker for diagnostic STEMI.Age,CK and CKMB are independent risk factors for distinguishing STEMI from NSTEMI,UA and SAP.Age,total cholesterol,LDL-C,HDL-C,CK,CKMB and homocysteine were the predictors of differentiating myocardial infarction.TC,Both HDL-C and PLA2 are independent predictors of increased LDL-C levels in STEMI patients.The above research results have quite positive practical significance in the clinical diagnosis and treatment of ACS.