Study On The Relationship Between TCM Constitution Types And The Quantitative Levels Of Anti-HBc In HBeAg-positive Chronic Hepatitis B

Objective:We detected the quantitative levels of hepatitis B core antibody(anti-HBc)in serum of patients with HBeAg-positive chronic hepatitis B(CHB)in different TCM constitution types.In order to provide a theoretical basis for better preventing and treating CHB with TCM constitution theory,we preliminarily investigated the relationship between TCM constitution types and anti-HBc quantitative levels in HBeAg-positive CHB patients.Method:One hundred and thirty patients with HBeAg-positive CHB were investigated by TCM constitution questionnaire.We collected the general information,physical and chemical indexes of the patients,and used double-sandwich immunoassay to measure the quantitative levels of anti-HBc in serum of the patients.After that,we analyzed the relationship between TCM constitution types and anti-HBc quantitative levels and physical and chemical indexes of HBeAg-positive CHB patients.Result:1.A total of 130 patients with HBeAg-positive CHB were included in this study.Among them,122 cases were single constitution type,and 8 cases were mixed constitution type.In single constitution types,qi-depression type>dampness-heat type>gentleness type>yin-deficiency type>qi-deficiency type>phlegm-dampness type>yang-deficiency type>special diathesis type and blood-stasis type.In all cases,37 cases were qi-depression type(28.46%),35 cases were dampness-heat type(26.92%),20 cases were gentleness type(15.38%),and 16 cases were yin-deficiency type(12.31%),they were the common TCM constitution types in HBeAg-positive CHB patients,accounting for 83.07% of the total sample size.2.In different TCM constitution types of HBeAg-positive CHB patients,there were statistically significant differences in the distribution of ALT levels,HBV DNA levels and inflammation grades(P<0.05).3.There was no statistically significant difference in the distribution of fibrosis stages among HBeAg-positive CHB patients with different TCM constitution types(P>0.05).4.In different TCM constitution types of HBeAg-positive CHB patients,the distribution of quantitative anti-HBc levels was statistically different(P<0.05).5.There was a positive correlation between ALT levels and quantitative anti-HBc levels in HBeAg-positive CHB patients(r=0.444,P<0.001).6.In different ALT levels and inflammation grades of HBeAg-positive CHB patients,the distribution of quantitative anti-HBc levels was different,and the differences were statistically significant(P<0.05).While in different HBV DNA levels and fibrosis stages,the distribution of quantitative anti-HBc levels was not statistically different(P>0.05).Conclusions:1.In different ALT levels and inflammation grades of HBeAg-positive CHB patients,the quantitative levels of anti-HBc were different.The quantitative level of anti-HBc may be a reference index to evaluate the severity of CHB patients.2.In different TCM constitution types of HBeAg-positive CHB patients,the distribution of ALT levels,HBV DNA levels,inflammation grades and quantitative anti-HBc levels were different,which suggested that the TCM constitution types of CHB were closely related to the immune state and the severity of the disease.Therefore,it was more helpful for the prevention and treatment of CHB to evaluate the condition of CHB patients by combining the TCM constitution type,serological indexes and liver histological results.