| Objective:Through the clinical treatment of liver fire disturbing heart type Parkinson’s disease insomnia patients with Chaihu-jia-Longgu-Muli-Decoction,observe its role in reducing PSQI scores,improving TCM syndromes and increasing PDSS scores,in order to evaluate the clinical efficacy of Chaihu-jia-Longgu-Muli-Decoction in treating liver fire disturbing heart type PD insomnia,we hope to develop new ideas for TCM syndrome differentiation and clinical research of PD insomnia.Methods:Patients with PD insomnia treated at the outpatient department of Encephalology and Geriatrics of Henan Provincial Hospital of Traditional Chinese Medicine from January 2019 to December 2019 were selected,the 78 patients with PD insomnia that met the inclusion criteria were divided into a treatment group and a control group according to the random number table method,with 39 cases in each group.The control group received sleep hygiene education and oral eszopiclone tablets on the basis of anti-PD drug treatment,the treatment group was given Chaihu-jia-Longgu-Muli-Decoction based on the treatment of the control group,the treatment and observation courses were 4 weeks.Observe the PSQI scores,TCM syndrome scores and PDSS scores for both groups of patients pre-treatment and 4weeks later of treatment.Use SPSS21.0 statistical analysis software to analyze all data,to compare and evaluate the clinical efficacy of the both groups.Results:(1)Comparison of PSQI scores: The total PSQI scores and individual scores of patients in the two groups after 4 weeks of treatment were all reduced than before treatment(p<0.05),and the total PSQI scores and individual scores of the treatment group were lower than those of the control group(p<0.05).(2)Comparison of TCM Syndrome scores: The total scores of TCM syndromes of patients in the two groups after 4 weeks of treatment were all reduced than before treatment(p<0.05).The individual scores of TCM syndromes of the treatment group were all reduced than before treatment(p<0.05).Individual scores of TCM syndromes(excluding head or limb tremor / less movement)of the control group were reduced than before treatment(p<0.05).and the total scores of TCM syndromes and individual scores of the treatment group were lower than those of the control group(p<0.05).(3)Comparison of PDSS scores: The PDSS scores of patients in the two groups after 4 weeks of treatment were all increased than before treatment(p<0.05),and the PDSS scores of the treatment group were higher than those of the control group(p<0.05).(4)Comparison of total effective rates of sleep quality: The treatment group was 92.11%,and the control group was 71.05%,the difference was statistically significant(p<0.05).(5)Comparison of total effective rates of TCM syndromes: The treatment group was 94.74%,and the control group was 57.89%,the difference was statistically significant(p<0.05).Conclusion:Chaihu-jia-Longgu-Muli-Decoction combined with eszopiclone is effective in treating liver fire disturbing heart type PD insomnia,which can significantly improve the sleep quality and sleep efficiency of patients,shorten the time of falling asleep,extend the sleep time,at the same time can reduce the nighttime disorders of PD patients,improve the clinical symptoms of TCM,and it is significantly better than the clinical effect of eszopiclone alone in the treatment of PD insomnia.There are no obvious adverse reactions during the test,and the drug is reliable and safe,which is worthy of clinical promotion and application. |
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