Clinical Significance Of NLR And MLR In Guillain-barré Syndrome

Objective:Guillain-Barré syndrome(GBS)is a severe peripheral nervous disease that leads to muscle weakness and areflexia.We now commonly accept a synthesis that inflammation and immunity play key role in the pathogenesis of GBS.Many studies pointed out that neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),platelet-to-lymphocyte ratio(PLR)and albumin(ALB)are novel promising markers of inflammation or immunity.Our study aimed to evaluate whether these indicators were associated to GBS and its clinical significance.Methods:From January 2013 to December 2019,patients who were hospitalized in the Affiliated Hospital of Guilin Medical College and had been diagnosed as GBS and healthy people were collected,including age,gender,white blood cell(WBC),neutrophil count(NEUT),monocyte count(MONO),lymphocyte count(LY),platelet count(PLT),albumin(PLT),albumin-globulin ratio(AGR)and duration of hospitalization(DOH),NLR,MLR and PLR were calculated,and the influence and value of related indexes on GBS were analyzed by corresponding statistical methods.Results:1.The NLR、MLR、PLR in GBS group were also larger than those in the healthy group,the ALB was smaller than healthy group,the severe group also had higher levels of NLR and MLR compared to the mild group(P<0.05).2.NLR and PLR may be the risk factors for GBS(OR>1),ALB may be the protective factor for GBS(OR<1).3.The cut-off value of NLR for GBS occurrence and severity was 2.51 and 4.59,respectively.The cut-off values of MLR for GBS incidence and severity was 0.24 and 0.27.Conclusion:1.NLR,MLR,PLR and ALB all have the value of predict GBS,NLR and PLR may be the risk factors for GBS,ALB may be the protective factor for GBS.2.NLR and MLR have predictive value for the severity of GBS patients.3.NLR and MLR are the influencing factors of survival prognosis of GBS patients.