Retrospective Analysis Of Risk Factors Of Hypoproteinemia In Preoperative Period Of Lung Cancer

[Objective]To observe the changes of serum albumin level in the first three days after lung cancer operation,and to explore the risk factors of hypoproteinemia in the early stage after lung cancer operation,so as to provide clinical basis for the prevention and treatment of hypoproteinemia in the early stage after lung cancer operation.[Methods]Collected and sorted out the relevant data of 336 patients undergoing lung cancer surgery.The time was from December 2019 to December 2020.The patients who underwent surgery were all patients from the Second Department of Thoracic Surgery of Yunnan Cancer Hospital.Classify and record the blood biochemical test results of patients before and three consecutive days after surgery and the factors that may lead to hypoproteinemia after lung cancer surgery.The serum whiteness measured by blood sampling in the first three days after lung cancer surgery is used.The average protein(ALB)is the basis for grouping,divided into normal group:ALB≥40g/L(31 cases)and case group:ALB<40g/L(305 cases).Consult the relevant guidelines and literature,combined with your own clinical work,summarized the factors that may be related to hypoproteinemia in the early stage of lung cancer surgery,and selected 16 related factors into this study.The statistical software used is SPSS 25.0.After classifying all the data,select the appropriate method for single factor,multivariate and correlation analysis.All results are P<0.05 indicating that the difference is statistically significant.Through comparison,the changes of serum albumin in the first three days after lung cancer surgery were obtained,and all the results were summarized and analyzed to obtain relevant risk factors for hypoalbuminemia in the early stage of lung cancer surgery.[Results]A total of 336 patients who underwent lung cancer surgery in the Second Department of Thoracic Surgery in our hospital were included in this study.There were 199 males(59.23%)and 137 females(40.77%),aged 27-82 years old,with a median age of 56.00 years old.Hypoproteinemia(ALB<40g/L)occurred in 305 people(90.77%)after surgery.After surgical treatment,the serum albumin of the patients decreased significantly,from(46.79±3.10)g/L to(34.01 ±3.08)g/L.1.After repeated data analysis of variance:Comparison of albumin in the first three days after operation:The intra-subject effect is statistically different(F=470.432,P<0.001).It can be considered that the serum albumin is different at different time points,and the inter-subject effect is also statistical The difference of science(F=143.242,P<0.001),it can be considered that there is a difference in serum albumin between the<40g/L group and≥40g/L group.2.The results of univariate analysis showed that:by X2 test:the<40g/L group and the≥40g/L group were not statistically significant except for differences in gender,surgical methods,fever,and whether or not to clean the relevant lymph nodes.Difference;by the t test of two independent samples:the difference between the<40g/L group and the≥40g/L group is statistically significant(P<0.05)is age,intraoperative total amount of colloidal fluid/body weight,preoperative albumin level and Intraoperative total infusion volume/weight,the rest was not statistically different;after two sample rank sum test:<40g/L group and≥40g/L group intraoperative lens fluid/weight,intraoperative total blood loss,postoperative drainage The total amount was statistically different(P<0.05).3.Correlation analysis results show:Pearson correlation analysis:preoperative albumin,intraoperative total fluid/weight,age,intraoperative colloidal fluid/weight,and the occurrence of preoperative hypoproteinemia after lung cancer surgery Correlation(P<0.05),there is no correlation between the occurrence of hypoproteinemia and maximum body temperature in the early stage of lung cancer surgery(P>0.05),and the spearman correlation analysis:the occurrence of hypoproteinemia in the early stage of surgery and the total amount of postoperative drainage The amount of intraoperative lens fluid/body weight and the total amount of bleeding during the operation were correlated(P<0.05),and they were all negatively correlated.4.Logistic regression results showed that:gender,fever,postoperative total drainage,intraoperative total fluid/weight,surgical method,preoperative albumin were all statistically significant(P<0.05).[Conclusion]After lung cancer surgery,protein gradually decreased,and the largest decrease was on the second day after surgery.The protective factors for hypoproteinemia in the early stage of lung cancer surgery were male and preoperative serum albumin levels.The independent risk factors were the total amount of postoperative drainage,Total intraoperative fluid infusion/weight,operation method and fever.Clinically,these aspects should be focused on predicting and preventing the occurrence of hypoproteinemia in the first three days after lung cancer surgery,which can reduce the incidence of hypoproteinemia in the early stage of lung cancer surgery and the incidence of other complications and mortality.Important clinical significance.