Analysis Of Lactate Dehydrogenase (LDH) As A Marker Of Severity In Critical Ill Neonates

Objective:Our aim was to investigate the relationship between the early clinical course of neonatal intensive care unit(NICU)infants and lactate dehydrogenase(LDH)in plasma at admission.Methods:It was a hospital based non-randomized clinical study conducted at NICU in Second Affiliated Hospital of Kunming Medical University.Patients admitted during the period of six months from August 2019 to January 2020 were included.71 cases were enrolled in the study.Data were collected using the newborns medical records and interview sessions with the mothers.A checklist consisting of neonatal information.The neonatal information included hospitalization,clinical systems and signs,laboratory test results.Severity of illness was defined by Neonatal critical illness scoring(NCIS).Having score of 70 to 90 were included in the study.Their LDH values were analyzed to determine its predictability as a marker of severity.The application of SPSS 24.0 software was used for analysis of single factor and multiple factors<0.05 was statically significant.Results:LDH values in the critically ill neonates of age one day were found significantly high with mean value of 1162.2 U/L.The correlation coefficient between NCIS scores and LDH values was-0.872(P<0.05).There were significant negative correlations between the NCIS scores and LDH values of the neonate.Both the NCIS scores and LDH values were not in any way associated with the gender of the children and the types of the diagnosis given to them(P<0.05)。Conclusion:The serum LDH levels were significantly higher in the critically ill neonates of age one day.There was a negative relationship between NCIS scores and LDH,in other words,the higher LDH,the more severe the disease was.LDH could be a marker of severity in critical ill neonates.