The Exploration Of Six-meridian Distribution Characteristics And The Rules Of Clinical Traditional Chinese Medicine For Patients With Perspiration Syndrome From The Perspective Of Six-Meridian Theory

ObjectiveTo explore fundamental features and the rules of the distribution of six meridians in patients with perspiration syndrome,and to preliminarily analyze the factors which may influence the distribution and understand the laws of traditional Chinese medicine for people suffering from perspiration syndrome from the perspective of six meridians,in order to have relevant guiding significance on the clinical traditional Chinese medicine treatment for patients with perspiration syndrome.Methods213 cases of patients with sweating syndrome diagnosed by the endocrinology outpatient department from Shenzhen Hospital of Traditional Chinese Medicine during the whole year of 2019,have been included in the study,according to the inclusion and exclusion criteria we made.The general information,such as gender,age,course of disease,inducement,sweating condition,other clinical symptoms and treatment prescriptions were collected.We used Excel to establish a database,and analyzed each patient’s symptoms to differentiate their classifications about six meridians.With the help of SPSS26.0 and SPSS Modeler18.0 software,we finally summarized clinical characteristics of traditional Chinese medicine and the rules of the distribution of six meridians in patients with perspiration syndrome.Results1.213 patients with hidrosis syndrome participated in this study,including 124 males and 89 females,with a male-to-female ratio of about 1.39:1.Patients included ranged in age from 18 to 70 years old,with a mean age of 37.04±11.67.All patients included were diagnosed as spontaneous perspiration or night sweating,of which 162 cases were spontaneous and 51 cases were night sweats.In terms of course of disease,the number of patients with sweating syndrome more than half a year was 121,accounting for 56.80%of the total.For the inducement,there were 191 cases with no obvious inducement,10 cases with staying up late and overwork,7 cases with postpartum period,and 5 cases with exogenous diseases.2.In terms of the distribution of six meridians of perspiration syndrome,132 cases were identified as single meridian disease,74 cases were identified as double-meridian disease,and 7 cases were identified as triple-meridian disease.In the classification of single meridian disease,shaoyin disease and taiyin disease were more common,while in multiple meridian disease,the combination between taiyin and shaoyin,taiyang and taiyin,taiyang and shaoyin diseases were more frequent.3.In the analysis of factors related to the distribution of six channels of perspiration syndrome,Kruskal-Wallis test between gender or age and the distribution of six channels of perspiration syndrome both indicated that there was no statistical significance in the distribution of six channels of perspiration syndromes between different gender and age groups(P>0.05).The P value of Kruskal-Wallis test was 0.000 in the diagnostic classification of spontaneous and night sweats and the duration of the disease,suggesting that there were significant differences in the distribution of six meridians of perspiration syndrome in different diagnostic types of spontaneous and night sweats and duration of the disease.4.After syndrome differentiation and classification of six meridians of perspiration syndrome,the clinical medication rules of each meridian were analyzed only for Shaoyin disease and Taiyin disease,due to fewer cases of Taiyang disease,Yangming disease,Shaoyang disease and Jueyin disease and their insufficient TCM prescriptions.There were 49 patients classified into Taiyin disease,and their prescriptions of traditional Chinese medicine were collected.It has been recorded that 81 kinds of traditional Chinese medicinal materials were used,and the frequency of medication was 666 times.The medicines for tonifying deficiency were used the most frequently,followed by astringent medicines,dampclearing medicines,etc.The representatives of high-frequency traditional Chinese medicinal materials were Astragalus membranaceus,white atractylodes rhizome,glutinous rice root,poria cocos,lotus seed,wheat and codonopsis pilosula,and etc.In terms of medicinal property statistics,mild Chinese medicine was the most frequently used in these prescriptions,followed by warm,slightly cold,cold,hot medicine etc.About their taste,sweet medicine was the most,followed by spicy,bitter,astringent,light taste,etc.For these medicines’ meridian statistics,the order of meridians were spleen channel,lung channel,heart channel,kidney channel according to the frequency of Chinese medicine meridians.In the high-frequency medicine association analysis,the common pairs were generated among Astragalus membranaceus,Atractylodes macrocephala,glutinous rice root,lotus seed,poria cocos and codonopsis pilosula,and were divided into two categories by cluster analysis.The category of Shaoyin disease,included a total of 51 Chinese traditional medicine prescriptions,using 112 kinds of traditional Chinese medicinal materials.The frequency of Chinese medicine was 718 times,the most used to tonify deficiency,followed by astringent medicine,heat,water moisture penetration,etc.The high frequent medicines were poria cocos,astragalus membranaceus,prepared rehmannia root,chinese yam,cornus,cortex moutan,rhizoma alismatis etc.Medicines’ tropism in statistics,mild Chinese herbal medicines were used the most,followed by slightly warm,cold,slightly cold,warm,cool etc.As for medicines’taste in statistics,according to their frequency,sweet medicines took the top,followed by bitter,pungent,sour,etc.About the channel tropism of medicine,kidney channel was followed by liver,spleen,lung,heart,etc.In the association analysis,the commonly used medicine pairs were the combinations from high-frequency traditional Chinese medicines of Chinese yam,prepared rehmannia root,Cornus,rhizoma alismatis and Cortex moutan,which can also be divided into three categories by cluster analysis.Conclusion1.Most patients with perspiration syndrome are male,and young people between the age of 21 and 40 are more likely to suffer from perspiration syndrome.Clinically,all patients with perspiration syndrome in the study can be diagnosed as hyperhidrosis,which can be classified into two types,spontaneous perspiration and night perspiration.Patients with spontaneous perspiration outnumber those with night perspiration.Most patients suffer from perspiration syndrome for a long time,and there are no obvious inducement in terms of inducing factors.The inducement in turn may be staying up late and overwork,postpartum,and after exogenous disease。2.In terms of the distribution of six meridians of perspiration syndrome,single meridian disease is more common,including shaoyin disease and taiyin disease,and those with multiple meridian diseases are also often associated with the three meridians of taiyang meridian,shaoyin disease and taiyin disease.In studies about related factors,the distribution of six channels of perspiration syndrome is often not related to gender or age,but there is a significant difference in the distribution of six channels of perspiration syndrome in different diagnosis of spontaneous perspiration and night perspiration,and so the same about different duration of disease.3.Clinical medication of six-meridian differentiation classification for patients with perspiration syndrome:Medicines for taiyin disease are often tonifying qi、astringent and damp-clearing,and usually belong to spleen and lung channels,having mild,slightly warm tropism,and taste sweet.The representatives of high-frequency traditional Chinese medicinal materials for taiyin were Astragalus membranaceus,white atractylodes rhizome,glutinous rice root,poria cocos,lotus seed,wheat and codonopsis pilosula,and etc.Modified sijunzi、shenlingbaizhu、yupingfeng decoction are common frequently-used in taiyin disease.As for shaoyin disease,tonic medicines,not only to enrich qi,but also tonify blood and yin,are more commonly used,the following categories are astringent,heat-clearing Chinese medicines.From the property,flavor and meridian distributions of the medicines,most of them are mild,warm or cold,sweet herbal medicines,belonging to liver and kidney channels often.High-frequency medicines are poria cocos,Astragalus membranaceus,prepared rehmannia root,chinese yam,cornus,cortex moutan,rhizoma alismatis,glutinous rice root,etc.And we speculate that modified liuwei dihuang、suanzaoren、guipi decoction are more common frequently-used in shaoyin disease.