Clinical Observation Of Xiaojianzhong Decoction In The Treatment Of Insomnia Due To Taiyin Disease Based On The Theory Of Opening,closing And Pivoting Of Three Yin And Three Yang

Objective:Based on the theory of Opening,Closing and Pivoting of Three Yin and Three Yang,Xiaojianzhong decoction was used to treat patients with insomnia of Taiyin disease,and its clinical efficacy was observed and evaluated.The efficacy and safety of Xiaojianzhong decoction were compared with those of youzopiclone tablets,which showed the clinical practical value of the theory of Opening,Closing and Pivoting of Three Yin and Three Yang in the treatment of insomnia and highlighted the advantages of Traditional Chinese Medicine.Methods:124 insomnia patients who met the selection criteria were randomly divided into experimental group and control group,62 cases in each group.Xiaojianzhong decoction was used in the experimental group and right zopiclone was used in the control group.The treatment period was 2 weeks,and the sleep disorder assessment scale(SDRS)was used before and after treatment The patients were evaluated by PSQI and TCM syndrome observation table.The clinical efficacy and TCM syndrome efficacy of the two groups were evaluated and compared.The recurrence was evaluated and compared with the two groups during the follow-up period of 2 weeks,and the recurrence was evaluated and compared by SDRS at the fourth weekend or the follow-up period.The adverse reactions of the two groups were statistically analyzed and the safety evaluation and comparison were made.Results: 1.In the analysis of clinical efficacy of insomnia,the effective rate of the experimental group was 86.44%,the apparent efficiency was 50.85%,the effective rate of the control group was 84.48%,the apparent efficiency was 44.83%,and the comparison was not statistically significant(P>0.05).2.In terms of TCM syndrome efficacy,the effective rate of the experimental group(89.83%)was higher than that of the control group(44.83%),and the significant efficiency of the experimental group(35.59%)was higher than that of the control group(8.62%),and the comparison was statistically significant(P<0.05).3.In the continuous effect,the recurrence rate of the experimental group(15.69%)was lower than that of the control group(44.90%),and the comparison was statistically significant(P<0.05).4.in the safety evaluation,the incidence of adverse reactions in the experimental group(1.69%)was lower than that of the control group(13.79%),and the comparison was statistically significant(P<0.05).Conclusion:1.Under the guidance of theory of Opening,Closing and Pivoting of Three Yin and Three Yang,Xiaojianzhong decoction has a definite effect on insomnia of Taiyin disease.Xiaojianzhong decoction has the same effect as dexzopicolone tablet in improving sleep of insomnia patients of Taiyin disease.The former had better effects on improving daytime functions such as early wakefulness and fatigue,daytime sleepiness and somnolence,while the latter had better effects on shortening the time to fall asleep.2.Compared with dexzopiclone tablet,Xiaojianzhong decoction can not only improve the sleeping condition,but also improve the symptoms of Traditional Chinese Medicine such as chills,lethargy,dull abdominal pain and loose stools.The overall effect is better.After treatment,the recurrence rate is low and the continuous curative effect is good.Xiaojianzhong decoction in the treatment of insomnia of Taiyin disease has a low incidence of adverse reactions and is safer in clinical use.It highlights the advantages of the overall adjustment of TCM and the principle of seeking the root of the disease.3.During the study,the insomnia treatment of Taiyin disease under the guidance of the theory of Opening,Closing and Pivoting of Three Yin and Three Yang has achieved expected results,indicating that the Theory of Opening,Closing and Pivoting of Three Yin and Three Yang has important clinical application value and guiding significance.