Correlation Between Different TCM Syndrome Differentiation And Renal Function Indexes Of Subcortical Arteriosclerotic Encephalopathy

Objective: To study the correlation between different TCM syndrome differentiation types and renal function indexes of subcortical arteriosclerotic encephalopathy(SAE),and to provide evidence and new ideas for TCM treatment of SAE.Methods: Selection of Qingdao city hospital of traditional Chinese medicine conforms to the diagnostic criteria of SAE 200 cases of patients,the vascular dementia syndrome scale(SDSVD)into the cases for parting,calculate the patient’s level of GFR,measured in patients with Scr,UA,Cys C,in different Chinese medicine dialectical classification in the SAE(Kidney essence deficiency,phlegm turbidity obstruction,blood stasis obstruction collaterals,liver Yang hyperactivity,heat toxin accumulation,viscera stagnation and retention,Qi and blood deficiency)and the correlation of the renal function indexes.Results:(1)Among the 200 cases included,the male to female ratio was 1.9:1.(2)In terms of age distribution,the age group of 75-84 years accounted for the largest proportion,and the mean age of each syndrome type was 70.23 years.(3)The distribution of TCM syndromes of SAE was the most in the hyperactive type of liver and Yang,and the least in the hyperactive type of heat and toxin.(4)Correlation analysis between SAE TCM syndromes and renal clinical indicators: GFR level among various syndromes was the lowest in renal essence deficiency type,which was statistically significant compared with blood stasis type(P<0.05).Comparison of UA levels among various syndrome types: Kidney-essence deficiency type was the highest,followed by liver Yang hyperactivity type and viscera stagnation and retention type.Kidney-essence deficiency type and liver Yang hyperactivity type had statistical significance compared with phlegm turbidity blocking orifices type,blood stasis obstruction collaterals type,heat toxin filling type and Qi and blood deficiency type(P<0.05).Compared with phlegm and turbidities blocking the orifices and blood stasis blocking the collateral system,there was statistical significance(P<0.05).The SCR level of each syndrome type was the highest in kidney essence deficiency type,followed by Qi and blood deficiency type,and the comparison between kidney essence deficiency type and phlegm turbidity obstruction and orifices type,liver Yang hyperactivity type,heat toxin accumulation type and viscera stagnation and retention type was statistically significant(P<0.05).There was statistical significance between Qi and blood deficiency type and heat toxin accumulation type(P<0.05).The level of Cys C among all syndrome types was the highest in kidney essence deficiency type,and there was statistical significance between kidney essence deficiency type and phlegm turbidity blocking the orifices,blood stasis blocking collaterals type,hyperactive liver Yang type,heat toxin filling type and Qi and blood deficiency type(P<0.05).(5)The levels of GFR,UA and SCR were statistically significant in the stages of SAE(P<0.05).Conclusion :(1)TCM classification of SAE patients has a certain correlation with the clinical indicators,and initially clarified that the quantification of renal function indicators of each syndrome type in SAE patients is feasible.The theory of "kidney-brain correlation" has been proved.(2)The distribution of TCM syndromes of SAE has nothing to do with age and gender of patients.(3)There was no significant correlation between different TCM syndromes of SAE and the grade of hypertension.(4)There was no statistical difference in the distribution of different TCM syndromes and basic diseases of SAE.(5)There was no significant difference between different TCM syndromes of SAE,stages of disease and grades of disease.(6)GFR level can be used as the basis for the differentiation of renal essence deficiency type.The UA level can be used as the basis for the syndrome differentiation of kidney essence deficiency type,liver Yang hyperactivity type and viscera stagnation and retention type.The level of SCR can be used as the basis for the differentiation of kidney essence deficiency and Qi and blood deficiency.The level of Cys C can be the dialectical basis of kidney essence deficiency type.(7)GFR,UA,and SCR levels were associated with disease progression in SAE.