| Objective: By collecting and analyzing the prescriptions of patients with chronic cough,comprehensively analyze the medication rules of Professor Wang Yanqing in treating chronic cough with traditional Chinese medicine,summarize Professor Wang’s clinical experience,and dig out the commonly used traditional Chinese medicine and drug pairs for this disease,so as to explore his academic thoughts and clinical thinking.Methods: In this study,Professor Wang Yanqing collected the medical records of 808 chronic cough outpatients in Qingdao Hospital of Traditional Chinese Medicine from January 2019 to January 2020 by using the TCM inheritance assistant platform system V2.5.Prescriptions were selected according to inclusion criteria and exclusion criteria for inclusion in this study.Input into the database of TCM "TCM Inheritance Assist Platform",review the data after input to ensure accuracy,and conduct data mining and statistics through TCM auxiliary traditional platform system.Results:1.The four qi of drugs were mainly warm(50.49%),followed by cold(23.27%)and flat(22.83%)drugs.The five flavors of the drug were mainly pungent(34.38%)and bitter(33.40%),followed by sweet(29.13%).The main channel of drugs was lung channel,accounting for 23.27%,followed by spleen channel(22.60%)and stomach channel(13.28%).2.A total of 808 prescriptions were included in this study,involving131 kinds of traditional Chinese medicine,and each prescription contained8.19 kinds of traditional Chinese medicine on average.The frequency of use of traditional Chinese medicine was 6620 times,with the most frequent use of poria cocos except prepared licorice.Frequency of usage of 20 or more drugs containing 51,main licorice respectively,tuckahoe,pinellia,radix bupleuri,dried tangerine or orange peel,platycodon grandiflorum,almond,radix scutellariae,atractylodes,dangshen,cassia twig,magnolia bark,angelica,white top,rhizoma alismatis,radix paeoniae alba,radix rehmanniae,dried ginger,Perilla,acid-insoluble ash,coix seed,rhizoma atractylodis,radix glycyrrhizae,radix peucedani,asters,ginger,jujube,grifola,yam,amomum fruit,white hyacinth bean,loquat leaf,fruit of Chinese magnoliavine,Fried atractylodes,radix rehmanniae,windproof,astragalus,asarum,gardenia,gentiana,plantain seed,also,Perilla leaf,bitter orange,purple Perilla,spurge,gypsum,cicada,rhizoma ligustici wallichii,magnolia flower,white mulberry;3.Based on association rules,set the number of support degrees as161 and the confidence degree as 0.85 in the formula rule to summarize the medication mode and medication rules.There were 58 drug use patterns with a frequency of >20%,and the occurrence frequency was more than 161 times,involving 12 traditional Chinese medicines.There were 58 medication rules,and the core drug combinations were as follows: Bupleurum-Radix Sutellariae-Pinellia trifoliata-Dangshen-Almond-Poria Cocos-Cinema Rhizoma-Tangerine Peel-Platycodon Platycodon-Magnolia officinalis-Sung Glycyrrhizae Rhizoma,from which prescriptions were obtained,such as Xiaochaihu Decoction,Liujunzi Decoction,Pinellia officinalis Magnolia Decoction,Linggui Zhugan Decoction,Poria Almond-Glycyrrhizae Decoction,etc;4.Based on cluster analysis,84 pairs of drug pairs with correlation coefficient ≥0.02 were extracted by setting correlation degree as 10 and punishment degree as 2;Based on complex system entropy clustering analysis,22 groups of core drug combinations were obtained.Based on unsupervised entropy hierarchical clustering analysis,11 potential new formulae were obtained :(1)Schisandra-precurum-Asarum-Aconiti-Zingiber;(2)Radix Platycodonis-Radix Scutellariae-Bupleurum-Radix Rehmanniae-Gentian;(3)shoot dry-semen lepidii-SSP-turmeric-ricepaperplant pith;(4)Radix Scutellariae-Pinellia formata-Radix Platyformis-Atractylodes;(5)Prunus porcine-Pinellia tuber-Atractylodes atractylodes-Amomum kernel;(6)Pinellia tuber-Poria cocos-Tangerine peel-Amomum kernel;(7)Bupleurum-Radix Paeoniae Paeoniae-Atractylodes Atractylodes-Citrus aurantii;(8)Bupleurum bupleurum-Poria cocos-Gentian aurantii;(9)Gardenia-Poria cocos-Gentian aurantii;(10)cassia twig-angelica-almond-ripe rehmannia glutinosa;(11)Parchment-Astragalus membranaceus-prepared liquorice-Alisma alisma-Tangerine peel.Conclusion: 1.Professor Wang Yanqing mainly used pungish and warm medicine to treat chronic cough,warming and reducing phlegm,promoting lung and relieving cough;2.The drug channel is mainly the lung channel,while taking into account the spleen and stomach,lung and spleen(stomach)with treatment;To pay attention to the pathogenic relationship between phlegm and chronic cough,the principle of drug use is to dissolve phlegm and stop cough,dissolve the surface and dissipate evil spirits,strengthen the root and strengthen the body.2.Professor Wang Yanqing treated chronic cough on the basis of the theory that "all the viscera and six fu-organs cause cough",and applied Sini powder and Longdan Xiegan Tang to treat "liver cough";Linggui Zhugan Decoction and Poria Almond and Glycyrrhizae Decoction were applied to treat "heart cough".Shenling Baizhu Powder and Liujunzi Decoction were applied to treat "splenic cough".Yupingfeng powder and Maimendong decoction were used to treat "lung cough".Jinshui Liujun decoction was used to treat "kidney cough".Small Chaihu decoction was used to treat "biliary cough".Pingwei powder was used to treat "stomach cough".Wuling San was applied to treat "bladder cough".3.Professor Wang Yanqing clinical often think of chronic cough and clamp with phlegm dampness,pathological factors such as water drinking,blood stasis,clinical application of pinellia soup,e.helioswpia decoction,cassia twig tuckahoe pills,therapeutic and subtract treatment,both the cheong lung qi activity,clinical and subtract platycodon grandiflorum,almonds,loquat leaf,hu,white before the carrier of lung qi drugs;4.Professor Wang Yanqing has rich clinical experience in the treatment of chronic cough.She combines four diagnoses with one syndrome,makes flexible syndrome differentiation analysis,and does not stick to one syndrome or one syndrome. |
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