| Objective:To observe the clinical efficacy of modified Zuogui Pill in the treatment of early-onset ovarian insufficiency of kidney yin deficiency syndrome.Methods:90 patients were randomly divided into three groups according to the number table method,30 cases in each group.The traditional Chinese medicine treatment group(group A)was treated with modified Zuogui Pill(nongben Fang);the western medicine treatment group(group B)was treated with estrogen and progesterone combined with sequential therapy(oral estradiol valerate tablets+progesterone capsules);the integrated traditional Chinese and Western medicine treatment group(Group C)was treated with modified Zuogui Pill(nongben Fang)combined with estrogen and progesterone Sequential treatment(oral estradiol valerate tablets+progesterone capsules);three groups were treated for three consecutive cycles,Before and after treatment,TCM syndrome scores(including menstrual cycle,menstrual volume,waist and knee soreness,dizziness and tinnitus,hot flashes and night sweats,five heart trouble,insomnia and dreaminess,vaginal dryness,decreased libido and other symptoms),serum sex hormone levels(FSH,LH,E~2),B-ultrasound related indicators(bilateral ovarian basal sinus follicle number(AFC),endometrial thickness(EM),bilateral ovarian volume)were observed,Objective to evaluate the clinical efficacy of modified Zuogui Pill in the treatment of early-onset ovarian insufficiency of kidney yin deficiency syndrome.Results:(1)Clinical efficacy comparison:the total effective rate of traditional Chinese medicine treatment group(group A)was 60.7%;the total effective rate of Western medicine treatment group(group B)was 70.3%;the total effective rate of integrated traditional Chinese and Western medicine treatment group(Group C)was 82.3%,H=8.64,P=0.01<0.05,the difference was statistically significant,the clinical efficacy of group C>group B>group A,that is,in terms of clinical efficacy,the treatment group of Chinese and Western medicine is higher than that of the western medicine treatment group,and the western medicine treatment group is higher than that of the traditional Chinese medicine treatment group.(2)TCM syndrome score comparison:three groups of patients before and after treatment:(1)menstrual cycle,menstrual volume group comparison(P<0.05),namely the three treatment groups in the menstrual cycle,menstrual volume have improved effect;three groups of patients after treatment group comparison(P<0.05),including a group and B group comparison(P>0.05),C group and a,B group comparison(P<0.05),namely the combination of traditional Chinese and Western medicine treatment The improvement of menstrual cycle and menstrual volume in the treatment group was better than that in the traditional Chinese medicine treatment group and the western medicine treatment group,and there was no significant difference between the latter two groups.(2)Compared with group A,group C(P<0.05)and group B(P>0.05),the TCM treatment group and the western medicine treatment group had an improvement in the aspects of soreness and weakness of waist and knee,dizziness and tinnitus,insomnia and dreaminess,and five heart trouble heat,while the Western Medicine treatment group had no obvious improvement;compared with group C after treatment,the difference was statistically significant(P<0.05)Compared with group A and group C(P<0.05),there was no significant difference in the improvement of waist and knee soreness,dizziness and tinnitus,insomnia and dreaminess,five heart trouble and heat between group B and group A and group C(P<0.05).(3)There was no significant difference between the three groups(P>0.05).(4)Compared with group B,group C(P<0.05),group A(P>0.05),that is,Chinese and Western medicine treatment group and Western medicine treatment group had improvement effect on the decrease of sexual desire and vaginal dryness,while Chinese medicine treatment group had no obvious improvement effect;compared with group B and group C(P>0.05),group A was compared with group B and group C(P<0.05)That is to say,the Chinese and Western medicine treatment group and the western medicine treatment group have the same improvement degree in reducing sexual desire and vaginal dryness,which are better than the traditional Chinese medicine treatment group.(3)Comparison of TCM syndrome total score:intra group comparison:the differences of TCM syndrome total score before and after treatment of three groups were statistically significant(P<0.05),that is,the TCM syndrome total score of three treatment groups had a downward trend after treatment;inter group comparison:the differences of TCM syndrome total score after treatment were statistically significant(P<0.05),and the total syndrome score of group C was lower than that of group A Group B,that is,in terms of the total score of TCM syndrome decline,the treatment group of TCM combination of Chinese and Western medicine is greater than that of the traditional Chinese medicine treatment group,and the traditional Chinese medicine treatment group is larger than the western medicine treatment group.(4)Comparison of serum sex hormone levels:comparison within the group:the differences of serum sex hormone levels before and after treatment in the three groups were statistically significant(P<0.05),that is,the three treatment groups had improvement in serum sex hormone levels.Comparison between groups:after treatment,the differences of serum sex hormone levels were statistically significant(P<0.05),including FSH,LH levels:Group C<group B<group A,E~2levels:group a<group B<group C,that is,in terms of reducing FSH,LH and increasing E~2levels,the integrative medicine treatment group is better than the western medicine treatment group,and the western medicine treatment group is better than the traditional Chinese medicine treatment group.(5)Comparison of B-ultrasound related indicators:comparison within the group:comparison of follicle number and endometrial thickness of bilateral ovarian basal sinus before and after treatment in three groups(P<0.05),that is,follicle number of bilateral ovarian basal sinus increased and endometrial thickness increased;comparison of bilateral ovarian volume(P>0.05),that is,ovarian volume had no significant change before and after treatment.Comparison between groups:after treatment,the number of ovarian basal sinus follicles and endometrial thickness in both sides were compared(P<0.05),among which group C was compared with group A and group B(P<0.05),and group A was compared with group B(P>0.05)After treatment,the volume of bilateral ovaries in the three groups was compared(P>0.05).Conclusions:1.In this study,the total effective rate of Integrated Chinese and Western medicine treatment group was 82.3%,the total effective rate of Western medicine treatment group was 70.3%;the total effective rate of traditional Chinese medicine treatment group was 60.7%,P<0.05,It shows that the treatment group of traditional Chinese and Western medicine has a certain clinical effect on patients with premature ovarian insufficiency of kidney yin deficiency syndrome.2.Jiawei Zuogui pill can effectively improve the TCM syndrome score(including menstrual cycle,menstrual volume,waist and knee soreness,dizziness and tinnitus,hot flashes and night sweats,five heart trouble and heat,insomnia and dreaminess),regulate the serum sex hormone levels(FSH,LH,E~2),increase the number of bilateral ovarian basal sinus follicles(AFC)and endometrial thickness(EM),To a certain extent,it can improve ovarian function and delay the process of premature ovarian failure.3.Jiawei Zuogui pill combined with sequential treatment of estrogen and progesterone can improve ovarian function. |
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