Study On The Medication Rule Of Professor Lu Jianqi On Chronic Heart Failure Based On Data Mining

Objective: To study the medication rule of Professor Lu Jianqi in treating chronic heart failure,CHF)in Guangxi,analyze the frequency of commonly used drugs of different syndromes,the law of meridian tropism and common drug combinations,and summarize the dialectical thinking,medication and diagnosis and treatment rule of Professor Lu Jianqi in treating CHF,so as to provide reference common drug pairs and new prescriptions for clinical treatment of CHF.Methods: From January 2018 to December 2020,the medical record data of CHF patients treated in the outpatient clinic of Professor Lu Jianqi,a famous Chinese medicine in Guangxi,the First Affiliated Hospital of guangxi university of chinese medicine,were taken as the research objects,and the medical record data with clear diagnosis of Chinese and Western medicine,perfect basic information,complete information of four diagnoses of Chinese medicine and clear information of prescriptions and medicines were selected.Establish a database after standardizing the included medical record data,and make statistics on age distribution,sex composition ratio,syndrome type distribution and etiology/high risk factors,and make statistics on clinical symptoms,tongue pulse condition,medication frequency,meridian tropism of common drugs,medication pattern,drug association rules and drug cluster analysis for each syndrome type V3.0 According to the statistics of commonly used drugs of different syndromes,the laws of the nature and taste of drugs and the common drug combinations of each syndrome,the dialectical thinking,medication and diagnosis and treatment laws of Professor Lu Jianqi in treating CHF were summarized,sorted out and refined comprehensively.Results: A total of 251 cases of CHF patients who met the standard were included in this study,and the results were as follows after being analyzed by using the auxiliary platform of traditional Chinese medicine inheritance(V3.0):2.The age of CHF patients included in this study is mainly from 50 to 89 years old(94.42%),and most of them are female patients,with 130 cases(51.79%).The etiology/high risk factors of patients mainly include coronary heart disease(54.98%),hypertension(34.66%)and valvular heart disease(21.51%).2.There are five main syndromes involved in this study,namely,Yang deficiency with flood(43.43%),Yang deficiency of heart and kidney(16.73%),deficiency of both qi and yin(16.33%),deficiency of qi and blood stasis(12.75%)and deficiency of heart and lung(10.76%).3.Statistical analysis of the common clinical symptoms of different syndrome types shows that the syndrome of yang deficiency and flood of water often has symptoms such as short breath,cold limbs,listlessness and edema of both lower limbs,and the tongue pulse condition is mostly pale tongue,thin white fur and thin pulse;Heart-kidney yang deficiency syndrome often has symptoms such as shortness of breath,spontaneous sweating,soreness of waist and knees,poor urination,chills and cold limbs,etc.The tongue pulse condition is often pale,with thin and white fur and thin pulse;Shortness of breath,night sweat,dizziness,tinnitus,spontaneous sweat,fatigue and other symptoms are common in deficiency of both qi and yin.The tongue pulse condition is more reddish,less moss and thin pulse;Qi deficiency and blood stasis syndrome often has symptoms such as shortness of breath,listlessness,chest tightness,aggravation of movement,and purple labial nails.The tongue pulse condition is mostly dark,thin and white coating,ecchymosis and thin pulse;Qi deficiency and blood stasis syndrome often has symptoms such as listlessness,shortness of breath,palpitation,asthma and cough,spontaneous sweat,etc.The tongue pulse condition is usually pale,with white fur and thin pulse.4.A statistical analysis of the four Qi,Wuwei and Guijing medications of different syndrome types found that the five syndrome types were mainly used for supplementing deficiency,warming,diuresis and dampness,and relieving surface drugs,among which surface relieving drugs It is mainly Guizhi;the four qi and five flavors are mainly warm and sweet;the return meridians are mostly the heart meridian,lung meridian,spleen meridian and kidney meridian.5.Statistical analysis of commonly used drugs of different syndrome types showed that 135 drugs were used in the syndrome of yang deficiency and flooding,including Astragalus membranaceus(95 times),Cinnamomum cassia twig(94 times),Poria cocos(86 times),Glycyrrhiza uralensis Fisch(80times)and Codonopsis pilosula(79 times).A total of 94 drugs were used in heart-kidney yang deficiency syndrome,including cassia twig(41 times),aconite root(38 times),Codonopsis pilosula(35 times)and Atractylodes macrocephala koidz(33 times).A total of 103 drugs were used in deficiency of both qi and yin,including Ophiopogon japonicus(43 times),Glycyrrhiza uralensis Fisch(38 times),Codonopsis pilosula(35 times)and Schisandra chinensis(34 times).A total of 78 drugs were used in the syndrome of qi deficiency and blood stasis,including Chuanxiong(30 times),Glycyrrhiza uralensis(28 times),Radix Paeoniae Rubra(27 times),Semen Persicae(25times)and Carthami Flos(23 times).A total of 88 drugs were used in the syndrome of heart and lung deficiency,including cassia twig(23 times),dangshen(23 times),astragalus membranaceus(21 times)and Pinellia ternata(20 times).6.Through the data mining of the auxiliary platform,Professor Lu Jianqi found 26 commonly used drug combinations(support degree is 54,confidence degree is 0.85)for treating CHF yang deficiency and flooding syndrome,involving 6 drugs;There are 19 commonly used drug combinations(support degree is 25,confidence degree is 0.90),involving 8drugs;There are 21 commonly used drug combinations(support degree is 22,confidence degree is 0.90),involving 6 drugs;There are 17 drug combinations of qi deficiency and blood stasis syndrome(support degree is21,confidence degree is 0.90),involving 6 drugs;There are 19 commonly used drug combinations(support degree is 14,confidence degree is 0.85),involving 7 drugs;Three groups of core drug combinations were obtained for each syndrome type(cluster number is 3).Conclusion:1.Among the 251 CHF patients treated by Professor Lu Jianqi,the syndrome of yang deficiency and water flooding is the most common,and the rest are syndrome of heart and kidney yang deficiency,qi and yin deficiency syndrome,qi deficiency and blood stasis syndrome,and heart and lung qi deficiency syndrome in order.2.Professor Lu Jianqi’s treatment of CHF is mainly tonic,warm,sweet and Guixin meridian,lung meridian,spleen meridian and kidney meridian;commonly used drugs such as Astragalus,Codonopsis,Guizhi,Aconite,Chuanxiong,Poria.3.Professor Lu Jianqi believes that the basic pathogenesis of heart failure is the deficiency of the essence and the deficiency of the substance,and the deficiency of the essence is the deficiency of qi and yang,and the symptoms of the deficiency are mainly blood stasis,drinking water,turbid phlegm,and permeate the disease.The development has always occurred.4.Professor Lu Jianqi’s treatment of CHF closely followed his academic thought of "treating the heart to warm the heart,warming the heart,spleen and kidney".While "warming and supporting the heart and yang",he often supplemented the spleen yang and assisted the kidney yang.