Clinical Observation Of Self-designed Tiaogan Yangxin Decoction In The Treatment Of Ejection Fraction Retention Heart Failure Accompanied By Anxiety

Object: To observe the effect of self-made prescription Tiaogan Yangxin Decoction on the clinical efficacy and quality of life of patients with preserved ejection fraction heart failure and anxiety state,and provide new ideas and references for TCM treatment of preserved ejection fraction heart failure with anxiety state.Methods: A total of 60 patients with HFp EF with heart-qi deficiency,qi-stagnation and blood-blocking HFp EF accompanied by anxiety were collected,and they were randomly divided into treatment group and control group,with30 cases in each group.The control group was treated with western medicine for anti-heart failure,and the treatment group was treated with self-made Tiaogan Yangxin Decoction,and the treatment was observed in 8 weeks.After treatment,the two groups of patients were compared and analyzed with TCM syndrome score,cardiac function grading effect,Lee’s heart failure score,plasma brain natriuretic peptide level,echocardiogram,anxiety score and other indicators,and observed and recorded the two groups of patients Three major routines and safety indicators such as liver and kidney function.Results:1.There was no drop-off in the two groups of patients,and the baseline data of the two groups of patients and the efficacy observation indicators before treatment were evenly distributed,and there was no statistical difference(p>0.05);2.Comparison of TCM syndrome scores: After treatment,the TCM syndrome scores of the two groups were significantly reduced(P<0.01).The TCM syndrome scores of the treatment group were significantly lower than those of the control group,and the total effective rate of TCM syndromes in the treatment group(90%)higher than the control group(70%)(P<0.05);3.Comparison of cardiac function efficacy: After treatment,the cardiac function classification of the two groups were significantly decreased(P<0.01),and the therapeutic effect of cardiac function classification of the treatment group was significantly better than that of the control group(P<0.01);4.Comparison of plasma brain natriuretic peptide levels(NT-pro BNP):NT-pro BNP in both groups decreased significantly after treatment(P<0.01).Compared with the control group,NT-pro BNP in the treatment group decreased significantly(P<0.01));5.Comparison of echocardiographic indicators: After treatment,the indicators of cardiac ultrasound in the two groups were improved(P<0.01).The left ventricular ejection fraction(LVEF)and mean e’(e The improvement of the mean value of’and lateral wall e’),E/e’ and left atrial volume index(LAVI)was better than that of the control group(P<0.05);but the two groups improved the peak velocity of left ventricular blood flow in the early and late diastole In terms of ratio(E/A),there was no statistical difference between the two groups(p>0.05);6.Comparison of Lee’s heart failure scores,the Lee’s heart failure scores of the two groups of patients were significantly decreased after treatment(P<0.01),and the treatment group was better than the control group(P<0.01).7.SAS anxiety score comparison: After treatment,the SAS score of the control group was not significantly improved compared with that before the treatment(p>0.05),and the SAS score of the treatment group was significantly lower than that before the treatment(P<0.01).Compared with the control group,the treatment group improved the patient’s anxiety score more significantly(P<0.01);8.Comparison of safety indicators: There was no significant difference between the three major routines and liver and kidney functions of the two groups of patients before and after treatment(p>0.05),and there was no adverse reaction.Conclusions: On the basis of western medicine treatment,the self-made prescription Tiaogan Yangxin Decoction can significantly improve the TCM syndrome score and anxiety score of patients with HFp EF accompanied by anxiety,relieve symptoms of heart failure,reduce plasma brain natriuretic peptide levels,and improve heart function.The mechanism of action may be related to the improvement of left ventricular diastolic function.The therapeutic effect is safe and effective,and it is worthy of further exploration.