| Objective: This project evaluates the clinical efficacy of self-made Shugan Hewei Recipe in the treatment of patients with functional dyspepsia due to liver-stomach discord by observing the clinical symptoms,psychological status and recurrence of patients before and after treatment.Methods: According to the random number table method,60 patients meeting the diagnostic criteria of FD were randomly divided into two groups,30 cases in each treatment group and control group.The treatment group was treated with self-made liver and stomach decoction,and the control group was treated with lansoprazole enteric-coated capsules combined with mosapride citrate tablets.The treatment course of the two groups was 4 weeks.Observe the overall clinical efficacy of the two groups of patients before and after treatment,the total TCM symptom scores,individual TCM symptom scores,psychological status,follow-up recurrence and safety,comparative analysis,statistical data,and conclusions.Results: A total of 3 cases were excluded,and a total of 57 cases were finally involved in the statistics,including 29 cases in the treatment group and 28 cases in the control group.⑴Clinical comprehensive efficacy comparison: the total effective rate of the treatment group was 96.55%,the total effective rate of the control group was71.42%,and the total effective rate of the treatment group was better than that of the control group(P<0.05).⑵Comparison of TCM symptom score: the total score of TCM symptom after treatment and total score before treatment were obviously different between the two groups(P<0.05).The total score of TCM symptoms in the treatment group after treatment was significantly better than that in the control group(P<0.05).⑶Single TCM symptom score comparison: The scores of various TCM symptoms of the two groups of patients(stomach fullness,Stomach pain,loss of appetite,early satiety,heartburn,belching and pantothenic acid,bitter mouth,dry mouth,uncomfortable stool,irritability,insomnia and dreaminess)were significantly lower than before treatment(P<0.05).The scores of various TCM symptoms of patients in the treatment group,except for full stomach,loss of appetite,early satiety,heartburn,belching and pantothenic acid,were significantly lower than those of the control group(P<0.05).⑷ Mental state comparison: The Hamilton Anxiety and Depression Scale was used to compare the mental states of the two groups before and after treatment.After treatment,the mental status scores,anxiety scores and depression scores of the two groups of patients were significantly lower than before treatment(P<0.05).The mental status scores,anxiety scores and depression scores of patients in the treatment group were significantly lower than those in the control group(P<0.05).⑸Quality of life comparison: After treatment,the total quality of life scores of the two groups of patients were significantly lower than before treatment(P<0.05).The total quality of life scores of patients in the treatment group were significantly lower than those in the control group(P<0.05).⑹ Comparison of recurrence: The recurrence rate of the treatment group was10.34%,the control group was 32.14%,and the recurrence rate of the treatment group was lower than that of the control group(P<0.05).⑺Safety analysis: the safety indexes of the two groups were not abnormal before and after treatment.No adverse reactions occurred during treatment.Conclusions: Self-made Soothing Liver and Stomach Recipe can relieve bitterness,cold and warm together,treat liver and stomach at the same time,clinically for liver-qi to invade the stomach,leading to block of qi mechanism in the spleen and stomach,hepato-gastric discordance caused by abnormal spleen and stomach Dyspepsia is better than the control group in terms of overall efficacy and improvement of clinical symptoms.It can significantly improve the quality of life of patients,and at the same time has the advantage of regulating the psychological state,with good safety and low relapse rate.Therefore,it can be further promoted. |
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