Pathological Observation And Analysis Of Neoadjuvant Chemotherapy For Cervical Cancer

ObjectiveObserve and analysis from the aspects of pathology of cervical cancer neoadjuvant chemotherapy on tumor cell killing effect and on the surrounding normal tissue damage,and further to evaluate the effect of cervical cancer neoadjuvant chemotherapy,curative effects and adverse effects of inductive indications and the indications of cervical cancer neoadjuvant chemotherapy,for cervical cancer neoadjuvant chemotherapy treatments pathological basis was provided for choice,At the pathological level,it provides a scientific basis for clinicians and patients to accept paclitaxel+ platinum neoadjuvant chemotherapy in the treatment of cervical cancer.Research Contents1.Qualitatively observe the killing effect of preoperative paclitaxel+platinum regimen neoadjuvant chemotherapy on the body cervical cancer cells and whether there is damage to the adjacent normal tissues to determine the efficacy and efficacy degree.2.To analyze the relationship between pathological changes and pathological effect after neoadjuvant chemotherapy for cervical cancer.3.To analyze the relationship between clinicopathological characteristics of patients and the pathological efficacy of neoadjuvant chemotherapy.Materials and MethodsA total of 98 cases of neoadjuvant chemotherapy tumor specimens and biopsy tissues before chemotherapy were collected from the Nanfang Hospital of Southern Medical University from 2017 to 2019,and 30 cases of normal cervical tissues were used as controls.Routine pathological examination and immunohistochemical examination were performed.Resected specimens of cervical cancer after neoadjuvant chemotherapy were observed under light microscope.According to the degree of tumor tissue dissipation,the efficacy of neoadjuvant chemotherapy after treatment was divided into 5 grades:grade 0 reaction,which was defined as complete disappearance of cervical tumor tissue;Grade 1 reaction,defined as cervical tumor tissue residue≤1/4;Grade 2 reaction,defined as cervical tumor tissue residue≤2/4;Grade 3 reaction was defined as cervical tumor tissue residue≤3/4;Grade 4 reaction was defined as residual>3/4 in cervical tumor tissue.Results1.4.1%of patients’ tumor tissues can be 100%killed,60.2%of patients’ tumor tissues can be partially killed,and 35.7%of patients have no obvious effect.2.Cervical cancer and normal cervical tissues adjacent to the cancer may have corresponding chemotherapy reactions to neoadjuvant chemotherapy:(1)The tumor cells have degeneration and necrosis,the number and density of tumor cells are reduced,and the cancer nest shrinks;nuclear vacuolation,appears Significant nucleoli.(2)Tumor interstitial fibrous tissue hyperplasia,with lymphocyte infiltration,fibrous interstitial mucoid degeneration,hyaline degeneration;foam-like tissue cell aggregation,cholesterol crystal fissure formation,calcification;(3)squamous normal cervical tissue adjacent to cancer The epithelial spinous layer is thickened,the cytoplasm is loose and transparent,the nucleus is enlarged,and vacuoles are formed.3.After neoadjuvant chemotherapy in patients with locally advanced cervical cancer,there is no significant statistical correlation between the pathological changes of tumor tissue and the efficacy of neoadjuvant chemotherapy.4.Compared with the ineffective group,the neoadjuvant chemotherapy effective group had lower rates of deep muscle infiltration,intravascular tumor thrombus,and lymph node metastasis,and the difference was statistically significant.5.Cervical cancer patients≤40 years of age have higher sensitivity to neoadjuvant chemotherapy,and it is easier to obtain significant and objective curative effects after neoadjuvant chemotherapy.Conclusion1.Neoadjuvant chemotherapy of taxanes combined with platinum drugs does has complete killing effect on tumor tissues of about 4.1%of patients;it has partial killing effect on cancer tissues of most patients;it has no obvious effect on 35.7%of patients.2.The normal cervical tissues adjacent to cervical cancer may have relatively mild damaging chemotherapy response to neoadjuvant chemotherapy.3.Neoadjuvant chemotherapy for cervical cancer patients<40 years of age is easier to obtain significant and objective curative effects.4.The effective neoadjuvant chemotherapy group can reduce some postoperative pathological risk factors.