| Objective:By studying the changes of serum MMP-9 level at 1d,3d,7d a nd 14d after the onset of acute ischemic stroke,to explore the changes of seru m MMP-9 level in the course of acute ischemic stroke patients,To further expl ore the reliability and practicability of detecting serum MMP-9 level in patients with acute ischemic stroke to assist diagnosis,monitor the course of disease,e valuate the severity of the disease and the prognosis.Methods:A total of 29 patients with acute ischemic stroke admitted to the Second Department of Neurology,New District Hospital of Chuxiong People’s Hospital from January 2020 to December 2020 were selected as the experimenta l group.Venous blood was collected 24h,3d,7d and 14d after the onset of the d isease in the experimental group,and 30 healthy subjects in the physical exami nation center of our hospital during the same period were selected as the contro l group.The level of MMP-9 was detected by ELISA method.To study the cha nges of serum MMP-9 levels 1d,3d,7d and 14d after the onset of the disease,to explore the change pattern of MMP-9 levels,and to further explore the reli ability and practicability of the detection of serum MMP-9 levels in patients wit h acute ischemic stroke to assist in diagnosis,monitoring the course of disease changes,and evaluating the severity of the disease and prognosis.All data were processed by statistical software SPSS 23.0.Measurement data were expressed a s mean±standard deviation((?)±s).Measurement data were analyzed by t-tes t method,and the correlation between indicators was analyzed by linear regressi on.Results:1.Serum MMP-9 levels in the experimental group were all higher than thos e in the control group at 1,3,7 and 14 days after onset,and the differences were statistically significant(P<0.05).2.There was no significant difference in serum MMP-9 level between the e xperimental group at 1,3,7 and 14 days after onset(P>0.05).3.According to NIHSS score,group A(≤8)and group B(>8)were divided into two groups to compare the serum MMP-9 level,and the difference was not statistically significant(P>0.05).According to Pearson correlation an alysis,the serum MMP-9 level at 1 day after onset could not be considered to be correlated with NIHSS score(P>0.05).4.There was no significant difference in the serum MMP-9 level between the small infarction group(≤25 cm~3)and the large infarction group(>25cm~3)at 1 day after onset(P>0.05).According to Pearson correlation analysis,the serum MMP-9 level at 1 day after onset could not be considered to be corr elated with cerebral infarction volume(P>0.05).5.According to the MRS score,they were divided into group C(0-2)an d group D(3-6).The serum MMP-9 levels of group C and group D were co mpared on 1 day and 7 days after the onset of disease,and there was no statis tical significance(all P>0.05).Conclusions:1.Serum MMP-9 levels were significantly higher than those in the control group at 1,3,7 and 14 days after cerebral infarction,suggesting that serum MMP-9 is extensively involved in the injury process of cerebral infarction and can be used as a marker of cerebral infarction.However,there is no exact rule with the course of disease,so it can not be used to monitor the course of dis ease.2.MMP-9 level at 1 day after the onset of the disease was not positively correlated with NIHSS score,cerebral infarction volume,and MRS score,and MMP-9 level at 7 days after the onset of the disease was also not positively c orrelated with MRS score,so it could not be used to predict the severity and p rognosis of cerebral infarction,which still needs further confirmation by more cl inical studies. |
PDF Full Text Request