Serum Matrix Metalloproteinase-2 In Patients With Acute Cerebral Infarction Toast Content Of The Sub-type In The Dynamic Changes And Significance

Objective To study the serial measurement and significance of matrix metaloproteinase-2 in serum of acute cerebral infarction patients according to TOAST criteria.Methods 77 patients with acute cerebral infarction and 42 healthy individuals were enrolled in this trial.All the patients were classified into five subtypes according to TOAST criteria.Serum MMP-2 level was measured in patients according to TOAST criteria at hour 24 and day 7,and healthy people by ELISA.And then the relationship between MMP-2 level and their TOAST subtypes were analysed.Results Of all the patients,37.66%,29.87%,16.88%,6.49%,9.09%were classified as 1 arge-artery atherosclerosis(LAA),small-artery occlusion lacunar(SAA), cardioembolism(CE),stroke of other demonstrated etiology(SOE),stroke of underdemonstrated etiology(SUE).Serum MMP-2 level of patients were significant higher than those of controls(p＜0.05);The level of the serum MMP-2 was much higher in patients with LAA SAA and CE than that in controls.As compared with the control group,The level of the serum MMP-2 in patients with LAA was the highest in ACI(P＜0.01).serum MMP-2 level of LAA at day 7 were significant higher than those of other subtypes and the control group.Conclusions The serum MMP-2 level varied with different subtypes of ACI,specially elevating in subtypes LAA,which surported that the subtypes varied according to different pathogenies.