Efficacy Analysis Of Drug Intervention In Children With Mild To Moderate Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To investigate the efficacy of mometasone furoate nasal spray and montelukast sodium chewable tablets in children with mild to moderate OSAHS,and to find a safe and effective treatment plan for children with OSAHS.Methods:This study retrospectively analyzed the symptoms of waking up at night,mouth breathing,snoring and other symptoms at the Pediatric Center of the First Affiliated Hospital of Xinjiang Medical University from December 1th,2018 to October 31th,2020,and improved sleep monitoring to confirm the diagnosis as mild to moderate.Children with mild to moderate OSAHS were randomly divided into nasal mometasone furoate nasal spray group（nasonide group）48 cases,montelukast sodium group（singulirine group）54 cases,combined There were 58 cases in the medication group,and general data of the children were collected:gender,age,weight,and BMI.All children recorded the results of sleep monitoring before and after 3 months of treatment and the disease specific quality of life for children with obstructive sleep apnea 18 items survey（OSA-18）scores.Results:（1）After drug treatment,the AHI of the combined drug group was lower than that of the pre-treatment and the same period of the single drug group,and the LSa O₂of the combined drug group was higher than the pre-treatment and the same period of the single drug group（P<0.05）,while the AHI,LSa O₂nasonide group compared with singulirine group,the difference was not statistically significant（P>0.05）;（2）After drug intervention,above three groups were lower in sleep disorders,emotional conditions,physical symptoms,impact on guardians,daytime functional status,and total scores.Before treatment,and the scores of the combination group were lower than those of the single ones（P<0.05）.There was no statistically significant difference in poor scores of Neshuna group in poor mood,daytime functional status and singulirine group in mood（P>0.05）;（3）The effective rates of treatment among the three groups were 47.92%,60.42%,and 89.58%,respectively.There were differences between the combination medication group and the Nesunar group and the Shunerning group（P<0.05）,but there is no statistical difference between the Nesuna group and the Shunerning group（P>0.05）.Conclusion:Both single and combined drugs can effectively reduce AHI and increase LSa O₂.The efficacy of combined drugs is better than single drugs;single and combined drugs can significantly improve the quality of life,and the combined drug group is better than the single drug group.