| Objective:The purpose of this study was to investigate the expression of p53,P16,Ki-67,CK7 and ER in cervical cancer and their relationship with clinicopathological features and prognosis.To provide theoretical basis for diagnosis,treatment and prognosis evaluation of patients with cervical cancer.Methods:The results of postoperative pathological immunohistochemical report of patients undergoing radical resection of cervical cancer in the first affiliated Hospital of Xinjiang Medical University were analyzed retrospectively.All the data are analyzed and sorted out by SPSS22.0.Results:1.The relationship between each immunohistochemical index and clinicopathological features:the index related to FIGO stage was p53;the index related to tissue differentiation was P16;the index related to tumor size was CK7;and the depth of cervical interstitial invasion;the index related to Ki-67;and lymph node metastasis was P16 and Ki-67.2.The relationship between each immunohistochemical index and PFS,OS:the expression of p53 was significantly correlated with PFS,and the expression of P16 was significantly correlated with OS.There was no significant difference between the expression of other immunohistochemical indexes and PFS and OS.Conclusion:The expression of p53 was related to clinical stage,the expression of P16 was related to tissue differentiation and lymph node metastasis,the expression of Ki-67 was related to the depth of cervical interstitial invasion and lymph node metastasis,and CK7 was related to tumor size.The progression-free survival time of p53 positive expression was shorter,and cervical cancer was more likely to relapse.The total survival time of P16 positive expression was shorter and the prognosis of cervical cancer was worse.Through the postoperative immunohistochemical report,we can determine the progress of cervical cancer tissue lesions,improve the clinical diagnostic value,and have a good prognosis for patients with cervical cancer. |
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