Relationship Between Platelet-Derived Growth Factor And Marrow-Sea Insufficiency Alzheimer’s Disease

Objective: To investigate the correlation between platelet-derived growth factor-BB(PDGF-BB)and Alzheimer’s disease with marrow sea deficiency syndrome.Method: A case-control study was conducted.The study included 50 AD patients with marrow-sea deficiency syndrome,50 patients with MCI and 50 volunteers with normal cognitive function matched with age and education were selected as the control group,they all attended the Fourth Clinical Medical College of Xinjiang Medical University during the time period from August 2019 to December 2020.Complete the Mo CA scale,MMSE scale,CDR scale and ADL scale by comparing the clinical baseline data of the three groups of patients(including age,gender,ethnicity,education level,course of disease,body mass index BMI,etc.),after collecting peripheral blood from three groups of patients,detect the level of PDGF-BB in serum by enzyme-linked immunosorbent assay(ELISA),using spss22.0 software for statistical analysis.Result:(1)The differences in age,education level,history of coronary heart disease,hypertension and diabetes among AD patients with myeloid deficiency syndrome are not significant,MCI patients and control group(P > 0.05),the data are comparable.(2)In terms of neuropsychological scale evaluation,the total score of MOCA and MMSE in AD patients with myeloid deficiency syndrome group are significantly lower than those in MCI group and control group,the difference is statistically significant(P < 0.01).The scores of the ADL scale and CDR scale of the AD marrow sea deficiency syndrome group are significantly higher than those of the MCI group as well as the control group.The difference is also statistically significant(P<0.01).According to the evaluation of the MMSE scale,except for language retelling,the scores of time orientation,spatial orientation,visual space,instantaneous memory,delayed recall,object naming,computing power,speech expression,and speech comprehension of the AD marrow sea deficiency syndrome group are also lower than the other two groups.The difference is statistically significant(P<0.05);In the evaluation of the MOCA scale,the visual space and execution ability,orientation ability,delayed recall,clock drawing experiment,naming,calculation,language,attention,as well as abstract ability scores of the AD group with deficiency syndrome are also lower than those of other two groups.The difference is statistically significant(P<0.05).(3)The content of PDGF-BB in serum: AD suihai deficiency syndrome group(7.48±3.81)ng/ml,MCI group(7.05±3.00)ng/ml,control group(6.48±4.47)ng/ml,comparison between the three groups is not statistical significance(P>0.05).In these three groups,the comparison between any two groups is not statistically significant(P>0.05).Conclusion: The level of PDGF-BB in serum may not be related to Alzheimer’s disease with marrow sea deficiency syndrome.