Correlation Between Urinary Microalbumin Level And Pan-vascular Diseases In Patients With Hypertension

Objective: To investigate the relationship between 24-hour urinary microalbumin level and the extent of pan-vascular diseases in patients with essential hypertension.Methods: A total of 377 patients with essential hypertension who were admitted to the First Affiliated Hospital of Xinjiang Medical University from July 2017 to December 2019 were selected as the subjects.Urine biochemical examination,coronary arteriography,renal arteriography,carotid ultrasound and cranial MRI were completed.According to the clinical data and the degree of vascular disease as the standard,the subjects were divided into the control group and the pan-vascular disease group.The general clinical data of the patients and the results of urinary microalbumin,coronary angiography and renal angiography were collected.Statistical methods were used to compare the differences in urinary microalbumin levels between the groups,and multivariate Logistic regression equation was used to analyze the risk factors of vascular diseases.Results:(1)The level of urinary microalbumin in the severe coronary artery stenosis group [9.38(4.76-16.72)] was significantly higher than that in the normal coronary artery group [5.40(3.05-8.35)].The level of urinary microalbumin in the high renal artery stenosis group [15.45(6.00-35.92)]was significantly higher than that in the normal renal artery group [6.30(3.95-10.78)].The level of urinary microalbumin in the carotid multiple plaque group [7.14(4.40-15.00)] was significantly higher than that in the normal carotid artery group [6.00(2.70-7.96)].The level of urinary microalbumin in lacunar cerebral infarction group [7.50(4.50-15.90)] was significantly higher than that in normal head group [6.30(3.60-9.81)],The above differences were statistically significant(P<0.05).(2)Multivariate Logistic regression analysis showed that: 24-hour urinary microalbumin was an independent risk factor for predicting the severity of coronary artery(OR 6.640,95%CI 2.688-16.405,P<0.01),renal artery(OR 38.400,95%CI 4.803-306.975,P<0.01),carotid artery(OR 7.645,95%CI1.636-35.736,P<0.01)and cerebral infarction(OR 4.131,95%CI 2.007～8.506,P<0.01)after adjusting for other risk factors in patients with essential hypertension.Conclusion:The level of 24-hour urinary microalbumin in patients with hypertension is closely related to the degree of coronary artery,renal artery,carotid artery and head lesions,and can be used as a clinical indicator to evaluate the degree of pan-vascular diseases.