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Clinical Study Of Yiqi Xiaozheng Granule Combined With Chemotherapy In The Treatment Of Advanced Gastric Cancer With Qi Deficiency,Blood Stasis And Phlegm Coagulation

Posted on:2022-08-13Degree:MasterType:Thesis
Country:ChinaCandidate:X J ChenFull Text:PDF
GTID:2504306317964189Subject:Chinese medical science
Abstract/Summary:PDF Full Text Request
Objective:The purpose of this study was to observe the clinical efficacy and safety of Yiqi Xiaoxiang granule combined with chemotherapy in the treatment of advanced gastric cancer with qi deficiency,blood stasis and phlegm coagulation,and to analyze the objective curative effect of solid tumor,KPS score,tumor markers,TCM syndrome scores and adverse reactions after treatment,so as to provide new ideas for the clinical treatment of advanced gastric cancer.Methods:In this study,68 patients with advanced gastric cancer were randomly divided into treatment group(n = 34)and control group(n = 34).The control group was treated with apatinib and capecitabine tablets.The treatment group was treated with apatinib and capecitabine tablets,21 days as a cycle,and the curative effect was evaluated every 2 cycles.After 4 cycles of treatment,the objective efficacy of solid tumor,physical status score(KPS score),gastric cancer-related tumor markers(CEA,CA199),TCM syndrome score and safety index of the two groups were statistically analyzed by SPSS26.0.Results:A total of 68 patients were included in this study,including 2 cases in the treatment group,3 cases in the control group,32 cases in the treatment group and 31 cases in the control group.(1)In terms of the objective curative effect of solid tumor,the objective remission rate and disease control rate of the treatment group were 40.63% and 87.5% respectively,while the objective remission rate and disease control rate of the control group were 32.26% and77.42%,respectively.Although the objective remission rate and disease control rate of the treatment group were higher than those of the control group,there was no significant difference between the two groups(P > 0.05).(2)In terms of physical strength,there was significant difference in the treatment group before and after treatment(P < 0.01),but there was no significant difference in the control group before and after treatment(P > 0.05).The difference was statistically significant(P <0.01).(3)In terms of reducing tumor markers CEA and CA199,there was no significant difference between the treatment group and the control group after treatment(P > 0.05),but there was significant difference in the level of CEA between the treatment group and the control group before and after treatment(P < 0.01).There was significant difference in the level of CEA in the control group before and after treatment(P < 0.05).(4)In terms of the efficacy of TCM syndromes,the overall efficacy of TCM syndromes was evaluated.After treatment,the effective rate of TCM syndrome improvement in the treatment group was 81.3%,while that in the control group was 64.5%.By rank sum test,the difference was statistically significant(P < 0.05).After treatment,the TCM syndrome scores of epigastric pain,abdominal distension,nausea and vomiting,fatigue,lack of appetite and loose stool in the treatment group were significantly lower than those in the control group,and the difference was statistically significant(P < 0.01).(5)In terms of adverse reactions: after treatment,the incidence of adverse reactions in the treatment group was lower than that in the control group,and there was significant difference in hypertension,leukopenia and thrombocytopenia(P < 0.05).Conclusion:Yiqi Xiaozheng granule combined with apatinib and capecitabine tablets in the treatment of advanced gastric cancer compared with apatinib and capecitabine tablets alone,it has obvious advantages in improving epigastric pain,abdominal distension,nausea and vomiting,fatigue,lack of appetite,loose stool and improving the physical condition of patients with advanced gastric cancer,and can improve the objective remission rate and disease control rate of patients with advanced gastric cancer.the incidence of adverse reactions decreased in varying degrees.It can be concluded that Yiqixiaoxiang granule combined with apatinib and capecitabine tablets can improve the clinical symptoms of patients with advanced gastric cancer,improve their quality of life,and reduce the adverse reactions of apatinib and capecitabine tablets with high safety and can be used for clinical use.
Keywords/Search Tags:Advanced gastric cancer, Yiqi Xiaozheng granule, chemotherapy, Qi deficiency,blood stasis and phlegm coagulation, Clinical study
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