Clinical Study Of Chaizhisijunxiaopi Decoction In The Treatment Of Postprandial Discomfort Syndrome Of Spleen Deficiency And Qi Stagnation

Objective:Chaizhi Sijun Xiaopi decoction was used to treat postprandial discomfort syndrome(postprandialdiscomfortsyndrome,PDS)of spleen deficiency and qi stagnation type as the starting point of clinical observation.The TCM syndrome scores and safety indexes before and after treatment were compared and statistically analyzed to evaluate its efficacy and safety.Methods:In strict accordance with the criteria set by this study,74 subjects were selected and randomly divided into two groups.The treatment group was treated with Chaizhi Sijun Xiaopi decoction(granule),and the control group was treated with Zhizhu Kuanzhong capsule for 2 weeks.After treatment,the TCM syndrome scores and safety evaluation of all subjects before and after treatment were summarized and evaluated.The data obtained from clinical observation were processed and analyzed by SPSS25.0 software.Results:1.General data analysis: the sex,age,course of disease,single TCM syndrome score and total score of the two groups were statistically tested,the results showed that there was no statistical significance between the two groups(P > 0.05),this study can be carried out.2.Comparison of the curative effect before and after treatment: the individual TCM syndrome scores and total scores of the two groups before and after treatment were statistically tested.The results of intra-group comparison showed that both groups of drugs were effective in the treatment of PDS with spleen deficiency and Qi stagnation,with statistical difference(P<0.05).3.Comparison of the curative effect between the two groups: the total effective rate was 93.94% in the treatment group and 77.14% in the control group,and there was statistical difference between the two groups(P<0.05).The comparison of total TCM syndrome scores between the two groups after treatment showed a statistical difference(P<0.05).The statistical test showed that Chaizhi Sijun Xiaopi decoction was superior to Zhizhu Kuanzhong capsule in the treatment of spleen deficiency and qi stagnation type PDS.4.Comparison of curative effect of single TCM syndromes: after treatment,the scores of single TCM syndromes of the two groups were compared between the two groups.In the treatment of epigastric distension or distension,daze,fatigue and loose stool,the curative effect of Chaizhijun Xiaopi decoction was better than that of Zhizhu Kuanzhong capsule(P < 0.05),while in the treatment of belching,the two groups had the same curative effect(P > 0.05).5.Comparison of long-term efficacy: two weeks after the end of treatment,the recurrence rates of the two groups were 13.8% and 37.5%,respectively,with statistical difference(P < 0.05),indicating that chaizhisijun Xiaopi decoction has better long-term efficacy than Zhizhukuanzhong capsule in the treatment of PDS with spleen deficiency and qi stagnation.6.There were no obvious adverse reactions in both groups before and after treatment.Conclusion : Chaizhi Sijun Xiaopi decoction is effective and safe in the treatment of postprandial discomfort syndrome of spleen deficiency and qi stagnation,which enriches the clinical treatment of this disease and is worth popularizing.