Clinical Observation On Treatment Of Chronic Primary Immune Thrombocytopenia With The Recipe Of Invigorating Spleen And Tonifying Kidney Combined With Western Medicine

Objective:By comparing Western Medicine and the recipe of invigorating spleen and tonifying kidney combined with Western Medicine treatment group on chronic primary immune thrombocytopenia(CITP)patient’ s platelet count(PLT),bleeding score,and quantitative scores of TCM syndromes Changes and adverse reactions before and after the treatment,to evaluate the clinical efficacy and safety of the recipe of invigorating spleen and tonifying kidney in it,and provide a safe and effective method for the treatment of CITP.Methods:All the 60 CITP patients from the Department of Hematology,Hubei Provincial Hospital of TCM from October 2018 to October 2019 were selected,and randomly divided into two groups with 30 cases in each group.There were no significant differences in the gender,age,bleeding score,TCM syndrome quantitative score and peripheral blood platelet count between the two groups(P>0.05).The control group was given basic treatment with western medicine,and the treatment group was given a prescription for invigorating the spleen and kidney on the basis of the control group(the specific composition includes astragalus,codonopsis,rehmannia,yam,fried atractylodes,tuckahoe,tangerine peel,dodder,morinda,Cynomorium,Cynomorium,Psoralen,agrimony,lotus root charcoal,cattail charcoal,licorice,etc.),treated for a total of 12 weeks,rechecked platelet count once a week,and followed up for more than 6 months.Observe and compare the changes of platelet count,bleeding score,quantitative score of TCM syndromes and adverse reactions before and after treatment between the two groups.SPSS 26.0 statistical software was used for data analysis,and the efficacy and safety of the recipe of invigorating spleen and tonifying kidney were evaluated.Results:1.There was no significant difference in gender,age,and duration of disease between the two groups(P>0.05).2.There was no significant difference in platelet counts between the two groups of patients before treatment(P>0.05).After treatment,the platelet counts were higher than before treatment(P<0.05),and the platelet count in the treatment group was higher than that in the control group(P<0.05).3.There was no significant difference in the bleeding scores of the two groups before treatment(P>0.05),the bleeding scores after treatment were lower than before treatment(P<0.05),and the reduction in the treatment group was higher than that of the control group(P<0.05).4.There was no significant difference in the quantitative scores of TCM syndromes between the two groups of patients before treatment(P>0.05),the quantitative scores of TCM syndromes after treatment were lower than before treatment(P<0.05),and the reduction in the treatment group was higher than that of the control group(P<0.05).5.Comparison of clinical efficacy between the two groups:the total effective rate of the control group was 86.21%,the total effective rate of the treatment group was 96.43%,and the total effective rate of the treatment group was higher than that of the control group(P<0.05).6.Comparison of the efficacy of TCM syndromes between the two groups of patients:the total effective rate of the control group was 68.97%,the total effective rate of the treatment group was 92.86%,and the total effective rate of the treatment group was higher than that of the control group(P<0.05).7.Comparison of safety between the two groups,Safety comparison between the two groups:the incidence of adverse reactions in the control group was 41.38%,the incidence of adverse reactions in the treatment group was 10.71%,and the incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion:1.The recipe of invigorating spleen and tonifying kidney combined with western medicine in the treatment of CITP is better than the western medicine treatment group in improving the patient’s platelet count,reducing the bleeding score,reducing the risk of bleeding,and improving the symptoms of patients.2.There was no obvious adverse reaction of liver and kidney in the treatment of CITP by using the recipe of invigorating spleen and tonifying kidney.In addition,it can also reduce the incidence of adverse reactions of prednisone to a certain extent,and has good safety.