Clinical Experience Of Professor Hu Xiaohua In The Treatment Of Polycystic Ovary Syndrome And Analysis Of The Regularity Of Medicamentosus Use

Objective: To summarize professor Hu Xiaohua’s academic thought and clinical experience in the treatment of PCOS,and to provide some reference for clinical treatment of the disease.At the same time,the data mining technology is applied to analyze the general condition,frequency of medication,four properties,five-flavor,mridian tropism,efficacy categories,and so on,discovering the prescription medication rule of Professor Hu Xiaohua in the treatment of PCOS,further improve his academic thought and experience and provide a new way of thinking and new method for the treatment of PCOS in the future.Methods: According to the criteria of inclusion and exclusion of PCOS,the clinical records of PCOS patients diagnosed and treated by Professor Hu Xiaohua in Henan traditional Chinese Medicine Hospital were screened out.Microsoft Office Excel 2016 was used to establish the database,and using related data analysis software,through frequency analysis,clustering analysis,association rules and other methods,including age,medicinal properties,drug efficacy,etc,combined with the actual situation of Professor Hu Xiaohua,the result of data mining were discussed and analyzed.Results: Of the 301 selected cases,301 prescriptions were obtained.The specific analysis was as follows:1 Age: The youngest age was 16 years old,the oldest age was 39 years old,the average age was26.4±4.2 years old;the 21-28 years old accounted for 52.8% of the total number,followed by 28-35 years old,accounting for 35.6%.The cumulative frequency of the two was 88.4%.Fewer patients were under 21 years old and over 35 years old,accounting for 7.6% and 4.0% respectively.2 Frequency distribution of drugs:Among 301 prescriptions,60 kinds of drugs were involved,32 kinds of drugs with frequency≥0.50% were used,the cumulative frequency was 87.49%;15 kinds of drugs with frequency≥3.00% were used,the cumulative frequency was 62.98%,in turn were Lycium barbarum,Dodder,Curculigo orchioides gaertn,Epimedium,Achyranthes,Eclipta,Ligustrum lucidum,Salvia mitiorrhiza,Angelica sinensis,Radix Paeoniae Alba,Ligusticum Chuanxiong,RadixRehmanniae,Radix-polygoni multiflorum,Antler frost.(Glycyrrhiza uralensis is often used in harmony,in order to reflect the characteristics of clinical use oflicorice,include it,but not rank it.)3 Distribution of medicinal properties of traditional Chinese medicine:(1)Four properties distribution of medicine: Warm drugs appeared most frequently,reaching1738 times,accounting for 31.85%;The second was cold,which appeared 1619 times,accounting for29.67%;Mild drugs,1412 times,accounting for 25.88%,and the cumulative frequency of the three drugs was 87.40%;And then were cool 410 times(7.51%)and heat 278 times(5.09%).(2)Five-flavor distribution of medicine: Sweet drugs accounted for 41.47%,followed by bitter(23.04%),spicy(18.25%),acid(9.91%),salty(2.96%),light(2.31%)and astringent(2.06%).(3)Meridian tropism distribution of medicine: Drugs were distributed in twelve channels and collaterals.According to the frequency of medication,the order of frequency(≥10.00%)was liver meridian(28.88%),kidney meridian(21.95%)and spleen meridian(12.35%);According to the number of medicines,the order of frequency(≥20)was liver meridian(34),stomach(22),kidney(21)and spleen(21).4 Distribution of efficacy categories of drugs: Drugs covered 11 categories,they were respectively tonifying deficiency medicine 57.42%(18 flavors),activating blood circulation and removing blood stasis medicine 14.04%(7 flavors),clearing heat and removing heat medicine8.08%(7 flavors),diuretics for eliminating dampness 7.24%(6 flavors),expectorant antitussive antiasthmatic medicine 3.02%(7 flavors),Qi-regulating medicine 2.99%(5 flavors),Astringent durg2.69%(1 favor),Antiepiphylaxis 1.63%(2 flavors),Digestant medicine 0.99%(4 flavors),Dehumidification medicine 1.70%(2 flavors),Liver-soothing and wind-soothing medicine 0.20%(1flavor).Among them,the cumulative frequency of tonifying deficiency medicine and activating blood circulation and removing blood stasis was 71.46%.The frequency of tonifying deficiency medicine from high to low was yang-tonifying medicine 1149 times(36.04%),yin-tonifying medicine 953times(29.89%),blood enriching medicine 728 times(22.84%),qi-invigorating medicine 358times(11.23%).5 New combination based on cluster analysis:(1)Fructus Aurantii Immaturus,Fructus Aurantii,Rhizoma Atractylodis,Pericarpium citri reticulatae viride,Tangerine Peel,Tiannan Star,Pinellia Ternata.(2)Moutan,Gardenia,Motherwort,Tulip,Salvia Miltiorrhiza,Bupleurum,Ligusticum chuanxiong,Safflower,Mint.(3)Achyranthes bidentata,Peach kernels,Rhizoma Cyperi.(4)Coptis chinensis,Scutellaria baicalensis,Trichosanthes,loquat leaves,Fritillaria thunbergii,Mulberry bark,Ophiopogon japonicus,Honeysuckle,Dandelion,Radix Scrophulariae.(5)Semen Coicis,Ecocarpium Benincasae,Poria cocos.(6)Hawthorn,Divine Comedy,Raphanus,Malt,Atractyloodes macrocephala,Lentil Bean,Licorice.(7)Angelica sinensis,Radix Paeoniae Alba.(8)E-clipta,Dendrobium,Ligustrum lucidum,Lycium barbarum,Rehmannia glutinosa,Polygonum multiflorum,Raspberry,Epimedium,Dodder,Curculigo orchioides Gaertn,Deer horn cream,Placenta hominis,Amethyst.(9)Oyster,Seaweed,Alisma orientalis,Plantain,Corn silk.(Neither lotus leaf nor other medicines formed a clustering relationship except lotus leaf.)6 Combination of drugs based on Association Rule Analysis:(1)Couplet medicines: Curculigo orchioides and Epimedium;Dodder and the fruit of Chinese wolfberry.(2)Triple drug combination: Curculigo orchioides,Epimedium,the fruit of Chinese wolfberry.Curculigo orchioides,Epimedium,Dodder.Dodder,the fruit of Chinese wolfberry,Epimedium.Dodder,the fruit of Chinese wolfberry,Curculigo orchioides.(3)Four-flavor drug combination: Curculigo orchioides,Epimedium,Dodder,the fruit of Chinese wolfberry.(4)Potential drug combinations: Eclipta,Ligustrum lucidum.Conclusion:1The incidence of PCOS is more common in women of childbearing age.2 The basic pathogenesis of PCOS is kidney deficiency and blood stasis,which is closely related to spleen deficiency,liver depression,phlegm turbidity and dryness heat.3 The treatment principle of PCOS is "tonifying,adjusting and unblocking",emphasizing the combination of prevention and treatment,regulating heart and mind,paying attention to classification and stages of treatment,and is good at the combination of Chinese and Western ginseng,in order to achieve the goal of disease and people’s peace.4 PCOS clinical medication,medicinal multi-temperature,cold,flat,taste more Gan,bitter,Xin,mainly attributed to the liver,kidney,spleen,stomach meridian,medication to tonify deficiency drugs,followed by blood-activating and stasis-removing drugs.5 Professor Hu Xiaohua’s commonly used couplet medicines are Curculigo orchioides and Epimedium,Dodder and the fruit of Chinese wolfberry.Triple drug combination: Cueculigo orchioides,Epimedium,the fruit of Chinese wolfberry.Curculigo orchioides Epimedium,Dodder.Dodder,the fruit of Chinese wolfberry,Epimedium.Dodder,the fruit of Chinese wolfberry,Curculigo orchioides.Four-flavor drug combination: Curculigo orchioides,Epimedium,Dodder,the fruit of Chinese wolfberry.Potental drug combinations: Eclipta,Ligustrum lucidum.6 The syndrome differentiation types of professor Hu Xiaohua in treating PCOS mainly includes kidney deficiency,Yin deficiency and stomach heat,phlegm-dampnss block and Liver-qi stagnation.