| Objective:To investigate the relationship between preoperative CEA,ca19-9 and clinical parameters in patients with gastric cancer and the value of predicting preoperative distant metastasis.Methods:Retrospective study from June 2013 to June 2017 were analyzed the clinical data of 324 patients with gastric cancer,all patients were received preoperative serum CEA and CA19-9 measurement,after collecting the related clinical data using single factor and multiple factors analysis preoperative level of CEA and CA19-9 values with the patient’s clinical parameters and the correlation of distant metastasis,and by using ROC curve preoperative CEA,CA199 cutoff value associated with distant metastasis preoperatively,set the best CEA forecasts with distant metastasis for gastric cancer patients,in addition to 64 patients with gastric cancer information collection,Group by the value and verify the reliability of the value.Results:CEA and CA19-9 before surgery in the study of patients with gastric cancer metastasis,collected a total of 324 patients with gastric cancer,the single factor analysis showed positive CEA preoperatively and lymph node metastasis,T stage,correlation TNM staging and distant metastasis(P = 0.000,P = 0.001,P = 0.001,P= 0.004),lymph node metastasis,multi-factor logistic analysis T staging are independent risk factors of gastric cancer patients serum CEA positive(P < 0.05),and gastric cancer patients serum CEA and distant metastasis were positively correlated(B = 0.231).According to the ROC curve,the best prediction value of CEA was 10.605ng/m L.If the serum CEA was greater than this value,the possibility of patients with gastric cancer with distant metastasis was considered to be high,and the prediction value of CEA was confirmed(P=0.002).Single-factor analysis showed that preoperative ca19-9 was correlated with lymph node metastasis(P=0.015),but not with distant metastasis in patients with gastric cancer(P > 0.05).Conclusion:Preoperative serum CEA value greater than 10.605ng/ml has certain clinical predictive value for the preoperative distant metastasis of gastric cancer,while serum ca19-9 has little clinical significance for the prediction of preoperative distant metastasis of gastric cancer.Objective: To investigate the value of preoperative CEA and ca19-9 in predicting postoperative distant metastasis of gastric cancer.Methods: Retrospective study from June 2013 to June 2017 treated 257 cases of Ⅰ-Ⅲphase of the clinical data of patients with gastric cancer undergoing surgery,all patients were received preoperative serum CEA and CA19-9 measurement,collecting the relevant clinical data and record its whether distant metastasis after two years,using the single factor and multiple factors analysis of CEA and CA19-9 patients with preoperative and postoperative clinical parameters the correlation of distant metastasis,and by using ROC curve preoperative CEA,CA199 and distant metastasis after cutoff value,the value is the best forecast to predict distant metastases postoperatively in patients with gastric cancer,Also collected in June 2017 to September 2017 Ⅰ-Ⅲperiod of gastric cancer patients undergoing surgery clinical data,carries on the two-year follow-up,filter and unable to track the follow-up of cases after death,get the data of 64 cases of gastric cancer patients,according to the predicted value is divided into two groups,to explore the correlation between two groups and distant metastasis after,to get the forecast for validation.Results: In the study of CEA,CA19-9 and postoperative distant metastasis in patients with gastric cancer,257 patients with gastric cancer were collected The results of single factor analysis showed that CEA positive before operation was correlated with lymph node metastasis,T stage,distant metastasis and TNM stage(P = 0.000,P = 0.005,P = 0.007,P = 0.010).Multi factor Logistic analysis showed that lymph node metastasis and distant metastasis after operation were independent risk factors for CEA positive in serum of patients with gastric cancer(P < 0.05),and CEA in serum of patients with gastric cancer was correlated with distant metastasis after operation The shift was positively correlated(B = 1.239).According to ROC curve,the best predictive value of serum CEA was 5.53ng/ml.If the serum CEA was higher than this value,it would indicate that patients with gastric cancer were more likely to have distant metastasis after operation.In addition,single factor analysis showed that CA19-9 was correlated with lymph node metastasis,tumor location and distant metastasis after operation(P = 0.001,P = 0.024,P = 0.002).Multi factor Logistic analysis showed that lymph node metastasis The best predictive value of Serum CA19-9 was 42.275u/ml according to ROC curve.If the value of Serum CA19-9 was higher than this value,it indicated that the possibility of distant metastasis was high.In addition,according to the follow-up data of 64 patients with gastric cancer,the results show that CEA is the best predictor of distant metastasis,but CA19-9 is not.Conclusion: Preoperative serum CEA > 5.53ng/ml has important clinical significance for predicting postoperative distant metastasis in patients with gastric cancer. |
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