Research Of The Correlation Between Porphyromonas Gingivalis And Clinicopathological Characteristics Of Cervical Squamous Carcinoma

ObjectiveTo investigate the infection situation of Porphyromonas gingivalis in patients with cervical squamous cell carcinoma,and to further analyze the correlation between Porphyromonas gingivalis and clinicopathological characteristics of cervical squamous cell carcinoma.Methods1.The subjects were divided into experimental group and control group,and the experimental group was the cervical squamous cell carcinoma patient of the first treatment,while patients with non-cervical cancer and precancerous lesions and excluding other malignant diseases were the control group.The Polymerase Chain Reaction(PCR)method was used to detect that if there were some differences in the expression of Porphyromonas gingivalis in patient’s oral cavity,cervical tissue and paracancerous tissue/vagina.2.Further analyzed the correlation of clinicopathological characteristics between Porphyromonas gingivalis and cervical squamous cell carcinoma.Results1.Among the 50 patients in the control group,26(52.0%)were positive for Porphyromonas gingivalis infection by oral swab test,6(12.0%)were positive for Porphyromonas gingivalis infection by vaginal swab test.However,Porphyromonas gingivalis was not detected in normal cervical tissue.It indicated that the infection rate of Porphyromonas gingivalis in normal cervical tissue was significantly lower than that in oral cavity(P<0.05).2.Among the 57 patients in the experimental group,37(64.9%)were positive for Porphyromonas gingivalis infection by oral swab test,20(35.1%)were positive for Porphyromonas gingivalis infection in cervical cancer tissue and 15(26.3%)in paracancerous tissue.Statistical analysis showed that the oral infection rate of Porphyromonas gingivalis in patients with cervical cancer was significantly higher than that in vagina and cancer tissues(P< 0.05).3.After further analysis of the infection rate of Porphyromonas gingivalis in expermental group and control group,the results showed that the infection rate in oral cavity,cancer tissue and paracancerous tissues of the experimental group was significantly higher than that in oral cavity,cervical tissue and vaginal mucosa of the control group,and the difference was statistically significant.4.Further analysis of the correlation between Porphyromonas gingivalis infection and clinicopathological characteristics of cervical cancer showed that there was no significant correlation between Porphyromonas gingivalis infection and age,lymph node metastasis,so the difference was not statistically significant.On the contrary,Porphyromonas gingivalis infection was positively correlated with human papillomavirus(HPV)infection,vascular thrombus,depth of tumor invasion,and P<0.05,so the difference was statistically significant.Conclusions1.The infection of Porphyromonas gingivalis may be a risk factor for cervical cancer,and Porphyromonas gingivalis may be one of the biomarkers of cervical cancer.2.The infection of Porphyromonas gingivalis is positively correlated with HPV infection,vascular thrombus and depth of tumor invasion of patients with cervical squamous cell carcinoma.Radical treatment of Porphyromonas gingivalis may reduce the occurrence and development of cervical cancer.