| Objective1.Through the method of clinical research,aiming at generalized anxiety disorder of stagnation of liver-qi(GAD),adopting acupoints catgut embedding and ordinary acupuncture for treatment respectively,and compare the curative effects of the two methods,so as to verify the clinical effectiveness,safety and reliability of acupoint catgut embedding in the treatment of GAD of stagnation of liver-qi.2.Explore the long-term effect of acupoints catgut embedding and ordinary acupuncture on GAD of stagnation of liver-qi.3.Form clinical technical operation specifications of adopting acupoints catgut embedding to treat GAD of stagnation of liver-qi.MethodsA total of 54 GAD patients were selected from network and the traditional therapy center of the Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine(Guangdong Hospital of Traditional Chinese Medicine).According to the principle of randomization,the patients were divided into two groups,the treatment group and the control group,with 27 cases in each group(one case in the treatment group fell off and 26 cases were finally included in the research).The treatment group was treated with catgut embedding therapy at points "Sihua acupoint"(Danyushuang and Geyushuang),once every 2 weeks and 4 times for 8 weeks in a row.The control group was treated with acupuncture according to the prescription:Baihui,Yintang,Shenmenshuang,Taichongshuang,Neiguanshuang,Tanzhong and Shimenshuang,3 times a week,once every other day,and 24 times for 8 weeks.Both groups were followed up twice at the 12th week and 16th week of treatment.The research adopted Hamilton Anxiety Scale(HAMA)score as the main efficacy evaluation index,Self-rating Anxiety Scale(SAS)score and traditional Chinese medicine symptom score as the secondary efficacy evaluation index.The clinical efficacy was evaluated by comparing the changes of the scores of the three scales before and after,and the overall efficacy was evaluated by "HAMA score reduction rate".The efficacy were evaluated at 4 nodes:the 4th week,the 8th week,the 12th week and the 16th week after treatment.At last,use the statistical analysis software SPSS 18.0 to count and analyze the research data.Results1.Comparison of baseline levelsThere was no significant difference between the two groups in gender,age,course of disease and other general conditions(P>0.05).There was no significant difference in HAMA score,SAS score and traditional Chinese medicine symptom score between the two groups before treatment(P>0.05).That is,the baseline level of the two groups is balanced which proves that there is comparability between the two groups.2.Comparison of the 4th week of treatmentIntra-group comparison:compared with the pre-treatment,the HAMA score,SAS score and TCM symptom score of both groups were significantly reduced(P<0.05).Inter-group comparison:there was no significant difference in HAMA score,SAS score and TCM symptom score between the two groups(P>0.05).3.Comparison of the 8th week of treatmentIntra-group comparison:compared with the pre-treatment,the HAMA score,SAS score and TCM symptom score of both groups were significantly reduced(P<0.05).Inter-group comparison:①HAMA score in treatment group was lower than that in control group,with significant difference(P<0.05);②there was no significant difference in SAS score and TCM symptom score between the two groups(P>0.05).4.Comparison of the 8th week of treatmentCompared with before treatment,taking"HAMA score reduction rate before and after treatment≥30%" as the effective standard,the total effective rate of the treatment group was 92.3%,and that of the control group was 63.0%,with significant difference between the two groups(P<0.05).5.Comparison of the 12th week of treatmentIntra-group comparison:①compared with before treatment,both groups can significantly reduce HAMA score,SAS score and TCM symptom score,with significant difference(P<0.05);②compared with the 8th week of treatment,there was no significant difference in HAMA score,SAS score and TCM symptom score between the two groups(P>0.05).Inter-group comparison:①HAMA score in treatment group was lower than that in control group,with significant difference(P<0.05);②there was no significant difference in SAS score and TCM symptom score between the two groups(P>0.05).6.Comparison of the 16th week of treatmentIntra-group comparison:①compared with before treatment,both groups can significantly reduce HAMA score,SAS score and TCM symptom score,with significant difference(P<0.05);②compared with the 8th week of treatment,there was no significant difference in HAMA score,SAS score and TCM symptom score between the two groups(P>0.05).Inter-group comparison:①HAMA score in treatment group was lower than that in control group,with significant difference(P<0.05);②there was no significant difference in SAS score and TCM symptom score between the two groups(P>0.05).7.Comparison of adverse eventsThere were 4 subcutaneous nodules in the treatment group(all of them were absorbed by themselves within 14 days),and no adverse events occurred in the control group.there was no significant difference between the two groups(P>0.05).Conclusion1.Acupoints catgut embedding is an effective therapy for the clinical efficacy of GAD of stagnation of liver-qi.The efficacy is exact,especially when "HAMA score" is taken as the main efficacy evaluation standard,the efficacy is better than that of ordinary acupuncture.2.In the 16th week of treatment(the 8th week of follow-up),acupoints catgut embedding and ordinary acupuncture have certain long-term effects on GAD of stagnation of liver-qi.When "HAMA score" is taken as the main therapeutic evaluation criterion,the long-term therapeutic effect of acupoints catgut embedding is better than that of ordinary acupuncture.3.For GAD of stagnation of liver-qi,acupoints catgut embedding is a characteristic therapy with simple operation,few side effects,high compliance,low time cost and lasting curative effect.At present,it has formed clinical operation specifications and is worthy of clinical promotion. |
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