Analysis Of Related Factors Of Anastotic Leakage After Anterior Resection Of Rectal Cancer

Objective:To investigate the incidence and risk factors of anastomotic leakage after anterior resection of rectal cancer.In order to provide the reference for reduce hanppenning rates of anastomotic leakageMethods:The clinical data of 243 patients with rectal cancer who underwent anterior rectal resection in our hospital from December 2014 to December 2019 were collected.The patients were divided into two groups:anastomotic leakage group(n=36)and non-anastomotic leakage group(n=207).The related factors of postoperative anastomotic leakage include age,ethnic group,sex,body mass index,hemoglobin,albumin content,distance of the tumor from the anal verge,complicated obstruction,tumor diameter,T stage of tumor,diabetes,operation time and mode and so on.Using chi-square test and binary Logistic regression analysis about various influence factors.Results:1.The incidence of anastomotic leakage in 243 patients was 14.8%(36/243),and the occurrence time was from the second day to the 17th day.2.The results of univariate analysis showed that sex,ethnic group,distance of the tumor from the anal verge,body mass index,combined obstruction and albumin content were closely related to the occurrence of anastomotic leakage,and the difference was statistically significant(P<0.05).Meanwhile anastomotic leakage was showed no association with age,tumor diameter,T stage of tumor,diabetes,hemoglobin,operation time and mode,the difference was not statistically significant(P<0.05).3.Binary Logistic regression analysis showed that Sex(OR=3.727,P=0.011),distance of the tumor from the anal verge(OR=2.620,P=0.027),body mass index(OR=2.600,P=0.018)and albumin content(OR=2.647,P=0.047)were independent risk factors for anastomotic leakage.Conclusion:Sex,distance of the tumor from the anal verge,body mass index and albumin content were independent risk factors for anastomotic leakage after anterior resection of rectal cancer.The related risk factors shoud be taken into consideration in clinical,develop individualized treatment plan to reduce the occurrence of anastomotic leakage.