| Objective:To observe the clinical efficacy and safety of soothing liver and reducing fire method recipe in the treatment of migraine with depression of qi stagnation transforming into fire,to explore the etiology and pathogenesis of migraine and depression with the theory of TCM,and to give full play to the advantages of TCM in the treatment of migraine and depression.To provide theoretical basis and new ideas for the treatment of migraine complicated with depression with TCM.Methods:Choose 62 patients From October 2017 to October 2018 from the Department of Encephalopathy,Weifang traditional Chinese Medicine Hospital who were diagnosed with migraine accompanied by depression of qi stagnation transforming into fire type,the patients were randomly divided into treatment group and control group with 31 cases in each group.The control group was treated with routine western medicine for migraine(if ibuprofen sustained-release capsule 0.3g was given in the acute stage for the first time,flunarizine hydrochloride capsule 10mg Qn was given after remission,and acute attack occurred again in the course of treatment)、The depression was controlled by venlafaxine hydrochloride sustained-release capsule 75mg QD,and the experimental group was treated with soothing liver and reducing fire basic recipe,one dose a day,half an hour after morning and dinner,on the basis of the control group.The TCM syndrome score,Hamilton depression scale(HAMD)score,migraine comprehensive score and quality of life score were compared between the two groups before and after treatment.The data were analyzed by SPSS22.0.The measurement data were expressed by mean±standard deviation(x±s),t test,counting data rate(%),χ2 test;The rank sum test was carried out on the measurement data and grade data which did not conform to the normality,P>0.05 had no statistical significance,P<0.05 had statistical significance,P<0.01 had significant statistical difference.Results:There were 1 case of exfoliation,31 cases in the final treatment group and 30 cases in the control group.After treatment,the scores of TCM symptoms,migraine,depression and quality of life in the treatment group and the control group were significantly improved(P<0.01),and the scores of TCM symptoms in the treatment group were better than those in the control group(P<0.05).Other scales.The score of the treatment group was significantly better than that of the control group(P<0.01).There was significant difference between the treatment group and the control group in the curative effect score of headache degree(P<0.05),and there was significant difference in the other curative effects between the treatment group and the control group(P<0.05).The symptoms of constipation appeared in the control group during the treatment,and the symptoms were improved after symptomatic treatment.there was no significant effect on the experimental study,and there was no significant change in the laboratory safety indexes of the two groups.Conclusion:Soothing the liver and reducing fire recipe can improve the headache degree,depression mood and quality of life of patients with qi stagnation transforming into fire type migraine and depression,and the safety titer is high,which is worth studying and popularizing. |
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