The Relationship Between Interstitial Lung Disease And Tumor Markers In Idiopathic Inflammatory Myopathy Was Discussed From The Point Of View Of The Theory Of Defensive Qi And Nutrient Blood

Research background and purpose:The most common type of inflammatory myopathy is PM/DM.Clinically,interstitial lung disease is a common complication of this disease.A few patients with acute interstitial lung disease develop rapidly,leading to respiratory failure and poor prognosis.The use of early immunosuppressive agents could positively alter the prognosis and improve the survival rate of PM/DM patients with ilds.The purpose of this study was to sort out and explore the clinical data of PM/DM patients,so as to improve the awareness of PM/DM combined with ilds,and early screening and identification of potentially combined PM/DM patients.Research methods:From January 2014 to August 2018,17 patients with pure PM/DM and 31 patients with combined PM/DM were hospitalized in the rheumatology and pulmonary diseases department of shandong hospital of traditional Chinese medicine and met the inclusion and exclusion criteria.General information,laboratory examination and clinical symptoms of patients were collected,and data were processed with SPSS software.Results:In the case of PM/DM alone,musculocutaneous symptoms(88%)were the main initial symptoms,while in the case of PM/DM combined with il-d,respiratory and fever were the main initial symptoms(54%)(P<0.05).In the case of PM/DM combined with ilillide,cough,pulvery-pulvery-white phlegm,chest tightness,and pulvery-pulverypulvery-lung were more likely to occur in patients with PM/DM(P<0.05).There was a significant difference in anti-robert52 antibody positivity between PM/DM alone and PM/DM combined with ilds(P<0.05),and it was most significant when anti-robert52 was positive +++,58% of which was quantitative positivity of PM/DM ANA 1:100,and 46%of which was quantitative positivity of PM/DM ANA 1:32.Cancer embryo antigen,CA153,CA125 and ferritin were significantly different between the two groups(P<0.05).According to ROC curve analysis,the AUC of cancer embryo antigen was 0.860(95%Cl=0.744-0.976),and the optimal threshold was 2.355ng/ml(sensitivity 66.7%,specificity 92.9%).Carbohydrate antigens CA125 AUC is 0.799(95% ci = 0.654 0.944),the best boundary value of 14.155 ц/ml(sensitivity 75.0%,specificity 85.7%);Carbohydrate antigen(CA153 AUC is 0.847(95% ci = 0.723 0.970),the best boundary value of 16.300 ц/ml(sensitivity 79.2%,specificity 85.7%);The AUC of ferritin was 0.78(95%Cl=0.631-0.929),and the optimal threshold was 429.7ng/ml(sensitivity 58.3%,specificity 92.9%).Correlation analysis of cancer embryo antigen,CA153,CA125 and ferritin with syndrome differentiation of "weiqi yingxue" showed P>0.05.Conclusion:The first clinical symptoms of PM/DM were mainly fever and respiratory symptoms,and it was found that there was no significant muscular skin symptoms.In the case of PM/DM combined with ilk,cough,phlegm oligowhiteness,chest tightness,and pulsar of lungs were more likely to occur.In patients with significant increase in creatine kinase,positive anti-robert52 antibody,and ANA quantification 1:32,it should be clinically noted whether there is any ilillarity.In patients with significantly increased carcinoembryonic antigen,CA153,CA125,and ferritin,it was suggested that there might be any possibility of cooperation in the field.Carcinoembryonic antigen,CA153,CA125 and ferritin may be related to ESS.There was no significant relationship between the syndrome differentiation of "weiqi yingxue" and carcinoembryonic antigen,CA153,CA125 and ferritin.