The Value Of Glycosylated Hemoglobin And Red Blood Cell Distribution Width In Evaluating The Development And Prognosis Of AECOPD

Objective: The purpose of this study was to evaluate the predictive value of erythrocyte distribution width（RDW）and glycosylated hemoglobin（Hb A1c）in predicting the disease severity and 1-year readmission in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and to provide a new direction for judging the condition and clinical prognosis of COPD.Methods: The data of patients hospitalized with AECOPD in the first Hospital of Lanzhou University from January 2018 to January 2021 were collected in the electronic medical record system,such as sex,age,smoking history,admission blood routine,pulmonary function parameters,hospitalization days,RDW at discharge and the number of acute aggravation and readmission within one year after discharge.The use of SPSS26.0 is used to analyze data.Results:1.The correlation analysis between research index and inflammation index shows that:（1）There was a positive correlation between Hb A1 c and CRP;（2）RDW was negatively correlated with EOS;（3）There was positive correlation between RDW and Hb A1 c.2.The relationship between RDW and the severity of AECOPD showed that there was a statistically significant difference in RDW between different grades of pulmonary function（P<0.05）,and the RDW value in all levels of pulmonary function was ranked as grade I < grade II < grade III < grade IV.3.To compare the difference of hospitalization time of patients with different levels of RDW and Hb A1c:the length of stay of patients with elevated RDW was longer than that of patients with non-elevated RDW,and the difference was statistically significant（P>0.05）.There was no significant difference in length of stay among patients with different levels of Hb A1c（P>0.05）.4.The relationship between the levels of RDW and Hb A1 c and the readmission of AECOPD patients within 1 year showed that neither of them was a risk factor affecting the number of readmissions in 1 year.5.By fitting the ROC curve,the predictive value of RDW and Hb A1 c on the deterioration of pulmonary function in patients with AECOPD re-admission was evaluated.The results showed that the areas under the curve of RDW-CV at admission,RDW-SD at admission,RDW-CV at discharge and RDW-SD at discharge were 0.635,0.639,0.676 and 0.680,respectively,and the product under the curve was 0.658.Conclusion: 1.RDW and Hb A1 c may be indicators of systemic inflammation.2.RDW is an independent risk factor for disease progression in patients with AECOPD.3.RDW is a potential biological indicator of prolonged hospitalization in patients with AECOPD.4.The levels of RDW and Hb A1 c have a certain predictive value for the deterioration of pulmonary function in patients with AECOPD,but the predictive value is low,and the combination of RDW+Hb A1 c cannot improve the overall predictive efficiency.