The Clinical Significance Of Peripheral Blood C-reactive Protein,Red Blood Cell Distribution Width,Fibrinogen And D-dimer In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Purpose:This study mainly focused on CRP,RDW,Fbg,D-dimer in peripheral blood.This study analyzed the differences between the 4 laboratory indicators and three groups including the stable phase of COPD,AECOPD group and the healthy control group.At the same time,the study further explore the correlation between the 4 laboratory indicators and lung function.It provides a predictive reference index for the clinical changes of COPD and the decline of lung function.Methods:This study is a retrospective study.A total of 107 patients who were diagnosed with COPD in the second affiliated hospital of Dalian Medical University from 2018 to 2020 were collected,including 48 patients in the acute exacerbation stage and 59 patients in the stable COPD stage.At the same time period,56 healthy normal persons who were examined in the physical examination center of the hospital were randomly selected as the healthy control group.Collect clinical data such as age,gender,smoking index,number of acute exacerbations within one year of the three groups of subjects,and record in detail the CRP,RDW,Fbg,D-dimer and other test indicators of peripheral blood of each subject as well as pulmonary function data such as FEV₁/FVC,FEV₁%pred,and then the difference analysis of each clinical index in different groups,and finally the correlation analysis of laboratory indexes and lung function indexes for all patients with COPD.Results:1.Compared with the three groups of subjects in terms of age（P=1.000）and sex ratio（P=0.182）,the difference was not statistically significant（P>0.05）.2.Compared with the normal healthy group,the RDW level of the COPD stable group was increased（P<0.05）,and CRP（P=0.219）,Fbg（P=0.106）,D-dimer（P=0.879）these three indicators were not significant difference（P values>0.05）.Compared with the stable phase of COPD,the levels of CRP（P=0.000）,Fbg（P=0.000）,and D-dimer（P=0.000）in the AECOPD group were increased（P values<0.05）,and the RDW level was not significant Difference（P=0.571）.3.Compared with the healthy control group,the levels of FEV₁/FVC（P=0.000）and FEV₁%pred（P=0.003）in the COPD stable group were significantly reduced（P values<0.05）;compared with the COPD stable phase,the FEV₁%pred value（P=0.000）of the AECOPD group was significantly decreased（P<0.05）,and there was no significant difference in FEV₁/FVC（P=0.969）.4.Peripheral blood CRP levels（r=-0.401,P=0.000）and Fbg levels（r=-0.367,P=0.000）in peripheral blood of patients with chronic obstructive pulmonary disease（including stable group and AECOOPD group）were significantly negatively correlated with FEV₁%pred,other laboratory indicators have not been found to be related to changes in lung function indicators.Conclusion:CRP and Fbg may be good indicators of inflammation that reflect the acute exacerbation of COPD,and are related to the decline of lung function.