The Study On Correlation Between Microinflammatory State And Proteinuria In Patients With Simple Obesity

Objective: The purpose of this study was to explore the correlation between the microinflammatory state and changes in proteinuria in patients with simple obesity.Methods: Retrospective system analysis in our hospital,2018-2019 weight metabolic branch weight loss surgery,205 cases of simple obesity in adults(except for a definitive diagnosis glomerular nephritis,diabetes,hypertension,coronary heart disease and heart failure patients),according to the preoperative clinical laboratory test in our urine trace albumin standard,divided the patients into three groups,namely without albuminuria group(urine trace albumin < 30 mg/L,n = 90),the trace albuminuria group(30 mg/L or less urine trace albumin < 200 mg/L,n = 92),a large number of albuminuria group(urine trace albumin or 200 mg/L,n = 23).The indicators of all subjects before weight loss surgery and three months after weight loss surgery were calculated,including: BMI,and serum creatinine(Scr),and blood uric acid(BUA),neutrophil count(Neu),lymphocyte count(Lym),neutrophil,lymphocyte ratio(NLR),fibrinogen(FIB),triglycerides(TG),high-density lipoprotein(HDL),triglycerides,high-density lipoprotein cholesterol ratio(TG/HDL)and urine trace albumin(Umalb)etc,for each index compared between groups.To observe the changes of urinary microalbumin,BMI,and micro-inflammatory indicators(NLR,FIB,TG/HDL)before and after weight loss,and to analyze the correlation between NLR,FIB,TG/HDL and urinary microalbumin.SPSS26.0 software was used for statistical analysis of all data,and P < 0.05 was considered statistically significant.Results: The results of variance analysis showed that body weight and BMI in the non-albuminuria group,the microalbuminuria group and the massive albuminuria group increased with the increase of urinary microalbumin level;In addition,NLR and TG/HDL in the three groups also increased with the increase of urinary microalbumin level,and the differences were statistically significant(P < 0.01).2.Pearson and Spearman correlation analysis showed that urine microalbumin in proteinuria group was positively correlated with body weight,BMI,TG/HDL and NLR(r=0.326,0.348,0.217,0.298)P < 0.05,but had no correlation with FIB level(P > 0.05).3.Logistic regression analysis showed that BMI,NLR and TG/HDL were risk factors for proteinuria in patients with simple obesity.4.The paired-sample test showed that 3 months after weight loss,the level of urinary microalbumin was significantly decreased with weight loss(P < 0.05),and the levels of microinflammatory markers NLR and TG/HDL were also decreased(P< 0.05).5.ROC curve analysis showed that BMI,NLR and TG/HDL could accurately predict the occurrence of proteinuria.Conclusion: 1.Obesity is a risk factor for proteinuria.The degree of obesity is positively correlated with proteinuria.2.The microinflammatory state of simple obese patients plays an important role in proteinuria.3.Weight loss through surgery can reduce proteinuria in patients,and the mechanism may be related to reducing inflammation.