Effects Of Eight-hour Restricted-time Feeding On Endocrine And Metabolic Profiles In Overweight And Obese Patients With Polycystic Ovary Syndrome

Objective:To explore the effects of eight-hour time-restricted feeding on endocrine and metabolic profiles in overweight and obese women with polycystic ovary syndrome(PCOS).Methods:18 initial-treated patients of PCOS with overweight and obese were enrolled from the endocrine clinic of Shengjing Hospital affiliated to China Medical University in2020.Eight-hour time-restricted feeding was provided for all subjects without medication.The experiment included maintaining a baseline period of one week’s previous diet and developing a daily diet between 8 a.m.and 4 p.m.for the next five weeks without the food type and the calorie limited.The forms of intervention include telephone Follow-up phone calls were conducted once every two weeks,and follow-up We Chat were conducted every week.Participants were provided with a food diary and instructed to record the daily beginning,and end of,food intake with calories.Changes in body weight,body mass index(BMI),Waist-to-Hip Ratio(WHR),skeletal muscle mass(SMM),body fat mass(BFM),body fat percentage(BF%),visceral fat area(VFA),luteinizing hormone(LH),follicle-stimulating hormone(FSH),LH/FSH,total testosterone(TT),sex hormone-binding globulin(SHBG),free androgen index(FAI),fasting glucose(FG),fasting insulin(FINS),homeostasis model assessment-insulin resistance(HOMA-IR),area under the curve(AUC)for insulin(AUCInsulin),area under the curve(AUC)for glucose(AUCGlucose),AUCInsulin/AUCGlucose Ratio,triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),uric acid(UA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),high-sensitivity C-reactive protein(hs CRP),menstrual cycle and eating behaviors were evaluated.Before and after the intervention,the changes of dietary habits during the intervention were evaluated by the 21 revised items of the three-factor diet questionnaire.Results:A total of 15 PCOS patients(age:22.27±3.92 years;BMI:29.75±4.31 kg/m~2)completed dietary intervention.After TRF intervention,significant changes were detected in(1)body weight(P<0.001),BMI(P<0.001),BFM(P<0.001),BF(P=0.012),VFA(P=0.015),(2)FINS(P=0.017),AUCInsulin(P=0.007),AUCInsulin/AUCGlucose(P=0.001),HOMA-IR(P=0.025),(3)TT(P=0.048),FAI(P=0.001),SHBG(P<0.001),(4)hs CRP(P=0.040)and ALT(P=0.027).The menstrual improvement rate was about73.3%(11/15).Daily intake of total calories were stable.There was no significant change in dietary habits before and after intervention.Conclusion:The five-week of eight-hour TRF can reduce the body weight,reduce androgen levels and increase insulin sensitivity in overweight or obese wowen with PCOS of childbearing age without changing energy intake.