| Objective:To analyze the correlation between serum Semaphorin3A(Sema3A)level with bone mineral density(BMD)and bone metabolic markers in patients with type 2 diabetes mellitus.Methods:A total of 129 patients with type 2 diabetes mellitus were collected.These patients were divided into osteoporosis group(n = 62)and non-osteoporosis group(n = 67).Clinical data of patients in both groups were collected,including gender,age,duration of diabetes,height,weight,and body mass index(BMI)was calculated.Glycosylated hemoglobin A1c(Hb A1c),25-hydroxy vitamin D(25(OH)D),calcium(Ca),magnesium(Mg),phosphorus(P),Type I procollagen amino-terminal peptide(PINP),osteocalcin(OC),β-Carboxy I terminal peptide(β-CTX),bone alkaline phosphatase(BALP),parathyroid hormone(PTH)and other indicators were measured.The serum Sema3 A level was detected by enzyme-linked immunosorbent assay(ELISA).The BMD of these patients was measured by dual energy X-ray absorptiometry(DXA).The correlation between serum Sema3 A level with bone mineral density and various bone metabolic indexes was analyzed by Spearman correlation analysis and multiple regression analysis.Results:The level of serum Sema3 A in type 2 diabetic patients with osteoporosis was lower than that in patients with non-osteoporosis(P <0.05).Spearman correlation analysis showed that the level of serum Sema3 A was positively correlated with lumbar spine BMD,total hip BMD,and femoral neck BMD(r=0.31,r=0.239,r=0.203,all P<0.05),and negatively correlated with OC(r=-0.177,P < 0.05),and negatively correlated with PINP、β-CTX,but not statistically significant(P>0.05).Multiple regression analysis showed that serum Sema3 A level was positively correlated with lumbar spine BMD(B=0.002,P=0.035)after correcting for confounding factors.Conclusions : In patients with type 2 diabetes,the level of serum Sema3 A was significantly decreased in the osteoporosis group.Sema3 A was positively correlated with BMD,and negatively correlated with OC、PINP、β-CTX. |
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