Study On Bone Metabolic Markers In Male Patients With Type 2 Diabetes Mellitus

Objectives1.Analyze the correlation between the level of glycosylated hemoglobin and the concentration of bone metabolic markers.2.Compare the relationship between bone mineral density test results and bone metabolic markers in male patients with type 2 diabetes mellitus.3.The objective was to screen early bone metabolic markers associated with osteoporosis in men with type 2 diabetes mellitus.methodsSelect 360 male patients with type 2 diabetes who met the inclusion criteria and were admitted to the endocrinology department from September 2018 to June 2020.1.Each patient’s case data was collected,including general information such as age,current medical history,past history,and weight.Patients who meet the entry criteria are divided into three groups according to the level of glycated hemoglobin(Hb A1c)in each age group,patients were divided into Hb A1c<7%;Hb A1c7%-9%;Hb A1c>9%,120 patients in each group,a total of360 patients.2.After examination,indicators related to bone metabolic markers detected during hospitalization included Calcium,Phosphorus,Parathyroid hormone.PTH,25-hydroxyvitamin D(25(OH)D),Osteoclast(OC),total type Iprocollagen carboxyl-terminal peptide(TPINP),and β-CTX.To analyze the correlation between Hb A1 c level and bone metabolism markers.3.Count the number of cases with bone mineral density test results among360 patients,divide them into three groups with normal bone density osteopenia and osteoporosis,analyze the changes in the concentration of bone metabolism markers in the three groups.Results1.The concentration of β-CTX,25(OH)D,Ca,PTH and P in the three groups was analyzed by variance(P>0.05),the difference was not statistically significant.The OC and TPINP concentrations in the three groups show a statistically significant difference by variance(P<0.05),and Pearson correlation analysis showed a negative correlation between OC and TPINP concentrations and the level of glycosylated hemoglobin.2.The comparison of TPINP and OC concentrations between normal BMD group and osteopenia group and osteoporosis group was statistically significant(P<0.05),and the two were positively correlated with BMD by Pearson correlation analysis.After the correlation analysis of β-CTX,25(OH)D,Ca,P and PTH,the difference was not statistically significant(P>0.05).Conclusions1.In this study,the worse the control of blood glucose levels under different glycated hemoglobin control levels,the lower the value of TPINP,osteocalcin concentration in male patients with type 2 diabetes.2.The differences of TPINP and OC concentrations between normal BMD group and osteopenia group and osteoporosis group were statistically significant(P<0.05).The differences of β-CTX,25(OH)D,Ca,P,PTH,P>0.05 were not statistically significant.3.The detection results of TP1 NP and OC can provide data support for the early diagnosis of osteoporosis in male patients with type 2 diabetes mellitus.