The Influence Of Modified Thoracic Nerve Block On Early Recovery Quality And Peripheral Blood Treg Cells In Patients Undergoing Modified Radical Mastectomy For Breast Cancer

Objective:To evaluate the influence of modified thoracic nerve block on early recovery quality and peripheral blood Treg cells in patients undergoing modified radical mastectomy for breast cancer.Methods:60 female patients who will undergo modified radical mastectomy were randomly divided into 3 groups:improved group(STG group)、traditional anterior serratus plane block general anesthesia(SG group)and general anesthesia combined with patient controlled intravenous analgesia(GP group).The percentages of the number of CD3+T,CD4+T,CD8+T and Treg cells in lymphocytes before,immediately after and 24 hours after surgery were detected;VAS scores were recorded at 30min,2h,4h,12h and 24h after surgery.One day before and 24 hours after surgery,15 recovery quality assessment scores;Sleep duration on the night after surgery;Intraoperative opioid dosage;Stop medication until time of awakening;Postoperative flurbiprofen ester dosage;Nausea,vomiting,dizziness,puncture site infection,pneumothorax infection and other adverse reactions.Results:The VAS score at 30min,2h,4h,12h and 24h after surgery in STG group was significantly lower than that in SG group and GP group(P<0.05),and the VAS score at 2h,12h and 24h after operation in SG group was significantly lower than that in GP group.24h postoperative QOR-15 score in STG group was significantly higher than that in SG group and GP group(P<0.05);The sleep duration of the night after surgery in STG group and SG group was higher than that in GP group,and the difference was statistically significant(P<0.05);The amount of opioids in STG group and SG group was lower than that in GP group;The time from drug withdrawal to recovery in STG group and SG group was shorter than that in GP group,the difference was statistically significant(P<0.05);Postoperative flurbiprofen ester dosage,STG group is less than the SG group and GP,SG group less than GP group,the difference has statistical significance(P<0.05)STG group the lowest incidence of nausea and vomiting and dizziness,statistically significant difference(P<0.05).Conclusion:There was no significant effect on the number of Treg cells in peripheral bloodeyword,the improved method of early postoperative thoracic nerve blockade can relieve pain,cells reducing the amount of intraoperative opioids,improve the quality of patients with early recovery,and no increase in adverse reactions.In a word,it’s a safe and effective perioperative analgesic method.