Study On The Correlation Between Obesity And Sex Hormones And Cytokines In Menopausal Women In Liangzhou District Of Wuwei City

Objectives To investigate the incidence of obesity in menopausal women in Liangzhou District,Wuwei City,and to explore the relationship between the occurrence of obesity in menopausal women and sex hormones,cytokines and blood lipids,so as to provide health guidance and preventive measures for preventing obesity in menopausal women and provide a theoretical basis for improving the health status of menopausal women and improving their quality of life.Methods According to the inclusion and exclusion criteria of this study,the natural female population aged 40-65 was selected from the cohort of natural populations aged 35-75 in Liangzhou District,Wuwei City,Gansu Province,and grouped and screened according to the body mass index 450 cases of women in the menopausal obesity group,450 cases of women in the menopausal normal group,450 cases of women in the non-menopausal obesity group and 450 cases of women in non-menopausal normal group were selected for the study of this subject,and then 50 cases were randomly selected from each of the four groups for laboratory serum testing.Cytokines and sex hormones were detected by 96-well enzyme-linked immunosorbent assay(Elisa),and the indexes of blood lipids were detected by automatic biochemical analyzer.Statistical analysis was performed using the c2 test and rank sum test,and multivariate logistic regression was used to analyze the main risk factors for obesity in menopausal women.Results 1.Waist circumference,BMI,body weight,body fat,muscle mass,bone mass,visceral fat,basal metabolic rate,body age,body water rate,triglyceride,low-density lipoprotein in the menopausal obese group-menopausal normal group were statistically significant differences by Kruskal-Wallis H rank sum test with multiple independent samples for multiple comparisons(P<0.05).2.There were statistically significant differences in age,waist circumference,body fat,muscle mass,bone mass,visceral fat,basal metabolic rate,body age,body water rate,estrogen,luteinizing hormone,triglyceride,low-density lipoprotein between menopausal obese group and non-menopausal obese group by Kruskal-Wallis H rank sum test with multiple independent samples for multiple comparison(P<0.05).3.There were statistically significant differences in age,height,waist circumference,BMI,weight,body fat, muscle mass,bone mass,visceral fat,basal metabolic rate,body age,body water rate,estrogen,luteinizing hormone tumor necrosis factor-α,triglyceride,total cholesterol,high-density lipoprotein,low-density lipoprotein,apolipoprotein B between the menopausal obese group and the non-menopausal normal group by Kruskal-Wallis H rank sum test with multiple independent sample multiple comparisons(P<0.05).4.Education level of high school and above [OR=0.216,95%CI(0.060-0.776)],height [OR=0.699,95%CI(0.592-0.825)],leptin [OR=0.191,95%CI(0.089-0.412)] were protective factors for obesity in menopausal women.Waist circumference [OR=1.124,95%CI(1.025-1.233)],body fat [OR=2.096,95%CI(1.710-2.568)],muscle mass [OR=2.119,95%CI(1.607-2.793)],visceral fat[OR=7.992,95%CI(3.852-16.580)],basal metabolic rate [OR=1.004,95%CI(1.001-1.007)],tumor necrosis factor-α[OR=1.013,95%CI(1.077-1.018)] and apolipoprotein A1[OR=151.670,95%CI(4.406-5221.059)] were the risk factors for obesity in menopausal women.Conclusions 1.Waist circumference,BMI,body weight,body fat,muscle mass,bone mass,visceral fat,basal metabolic rate,body age,triglycerides,total cholesterol,low-density lipoprotein,and apolipoprotein B were increased,but body water rate,estrogen,luteinizing hormone,tumor necrosis factor-α,and high-density lipoprotein were decreased in postmenopausal obese women.2.Education level,height and and Leptin were protective factors of obesity in menopausal women,and waist circumference,body fat,muscle mass,visceral fat,basal metabolic rate,tumor necrosis factor-α and apolipoprotein A1 were risk factors of obesity in menopausal women.3.Postmenopausal women have increased waist circumference,visceral fat,body age,and triglycerides,but decreased muscle mass,bone mass,basal metabolic rate,body water rate,estrogen,and luteinizing hormone,which may be the reason why postmenopausal women are prone to diseases such as obesity,osteoporosis,metabolic disorders,and other diseases.4.Waist circumference,BMI,body weight,body fat,muscle mass,bone mass,visceral fat,basal metabolic rate,body age,and triglycerides increased after obesity in women,but the body water rate decreased.