Correlation Between Intracompartment Pressure And Pulse Oxygen Saturation Of The Affected Limb Of The Patients With Venomous Snakebite

Objective:In order to identify snake venom-induced compartment syndrome(SVCS)at an early stage and reduce the severe disability and mortality of venomous snakebite,the correlation between SpO2 and ICP of the affected limb of a venomous snakebite was studied.Methods:Patients diagnosed with venomous snakebite admitted to the emergency department of the Affiliated Hospital of North Sichuan Medical College from June 1,2019 to October 30,2019 were selected.Collect the patient’s general information(name,age,gender,bite,blood pressure),laboratory examination during the first 24 hours(white blood cell count,neutrophil count,neutrophil percentage),swelling extent,such as clinical data,and to measure distal limb and the contralateral limb week of pulse oxygen saturation,diameter.Intracompartment pressure of the affected side was measured by Whitesides’ method.Results:1.Pulse oxygen saturation of the affected side was significantly lower than that of the healthy side,and the difference was statistically significant(P<0.05).The circumference of the affected side was higher than that of the healthy side,and the difference was statistically significant(P<0.05).2.The WBC count,neutrophil count and neutrophil percentage of snakebite patients with different limb swelling degrees were different.Patients with severe swelling were higher than those with moderate swelling group,the difference was statistically significant(P<0.01),while those with moderate swelling were higher than those with mild swelling group,the difference was statistically significant(P<0.01).WBC count and neutrophils count were strongly positively correlated with the degree of limb swelling of snakebite patients(Kendall’s Tau-b=0.697,0.667,P<0.01).The percentage of neutrophils was weakly positively correlated with the degree of limb swelling in snakebite patients(Kendall’s Tau-b=0.372,P<0.01).3.There was a highly negative correlation between WBC count,neutrophil count,neutrophil percentage,circumference difference and pulse oxygen saturation on the affected side,and the correlation was statistically significant(r=-0.880,-0.890,-0.646,0.916,P<0.05).4.There was a highly negative correlation between the intracompartment pressure of the affected side and the pulse oxygen saturation of the affected side,r=-0.945,P<0.05,and the correlation was statistically significant.There was a linear correlation between the two,and the regression equation was as follows:pulse oxygen saturation(%)=99.886-0.341× intracompartment pressure(mmHg)(F=378.093,P<0.01).Conclusion:In venomous snakebite,there is a negative correlation between intracompartment pressure and pulse oxygen saturation.The higher the intracompartment pressure is,the lower the pulse oxygen saturation is.Monitoring the pulse oxygen saturation at the end of the affected limb can indirectly reflect the ischemia and hypoxia of the affected limb.Combined with clinical symptoms,it is helpful for early identification of SVCS.